Figure 2

Comparison of 1- and 2-sided tests using only equal spike-ins as true negatives. ROC charts of Golden Spike data using a 2-sided and two 1-sided tests of DE, with only the equal spike-ins used as true negatives. Genes with FC of 1.2 are used as true positives, and no post-summarization normalization is used. We only show results for the FC DE detection method. The legend is the same as in Figure 1. The different charts show a.) probesets selected using a 2-sided test of DE, b.) probesets selected using a 1-sided test of up-regulation and c.) probesets selected using a 1-sided test of down-regulation. As with Figure 1, we include lines of no-discrimination.