Figure 8
From: Predicting cancer involvement of genes from heterogeneous data
Procedure followed to predict cancer gene candidates. First, a cancer protein interaction network is built from the list of known cancer genes. Second, expression data from different cancer types is mapped onto the network. Third, probabilities of being a cancer gene based on structural, functional and evolutionary properties are retrieved for proteins in the network. Fourth, cancer genes are predicted based on the thresholds provided by the user for each type of data.