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Table 5 Analysis of predicted cancer genes in Table 4. Column "related to cancer" indicates whether literature [43] and information coming from UniProt [44], Reactome [45] and GO [46] indicate a strong involvement in cancer (++), somehow related to cancer (+) or not related to cancer (-). Literature references for each gene found to be involved in cancer are provided as additional file 8.

From: Predicting cancer involvement of genes from heterogeneous data

Gene name Description and Function/Pathway Related to cancer
CDK9 Cell division protein kinase 9 Regulation of progression through cell cycle ++
GATA2 Endothelial transcription factor GATA-2 Transcriptional activator which regulates endothelin-1 gene expression +
ATF2 Cyclic AMP-dependent transcription factor ATF-2 Transcriptional activator which binds to the CRE, present in many viral and cellular promoters. +
CCNB1 G2/mitotic-specific cyclin-B1 Essential for the control of the cell cycle at the G2/M (mitosis) transition. ++
CSNK2A2 Casein kinase II subunit alpha Participates in Wnt signaling. +
PPARBP Peroxisome proliferator-activated receptor-binding protein Essential for embryogenesis. Plays a role in transcriptional coactivation ++
CSK Tyrosine-protein kinase CSK Negative regulation of cell proliferation ++
KIN27 Protein kinase A-alpha ATP binding and protein serine/threonine kinase activity -
CUL1 Cullin-1 Mediates the ubiquitination of proteins involved in cell cycle progression, signal transduction and transcription ++
DKFZP686I18166 Hypothetical protein ATP binding and protein kinase activity -
STAT5B Signal transducer and activator of transcription 5B Signal transduction and activation of transcription ++
MCM7 DNA replication licensing factor MCM7 Required for DNA replication and cell proliferation. Required for S-phase checkpoint activation upon UV-induced damage. ++
SURB7 Mediator of RNA polymerase II transcription subunit 21 Regulation of transcription. -
MST1R Macrophage-stimulating protein receptor [Precursor] Receptor for macrophage stimulating protein (MSP). Tyrosine-protein kinase activity. ++
KHDRBS1 KH domain-containing, RNA-binding, signal transduction-associated protein 1 Role in G2-M progression in the cell cycle. ++
SYK Tyrosine-protein kinase SYK Positive effector of BCR-stimulated responses. ++
KDR Kinase insert domain receptor Kinase activity and receptor activity. ++
NME2 Nucleoside diphosphate kinase B Major role in the synthesis of nucleoside triphosphates other than ATP. ++
POLR2B DNA-directed RNA polymerase II 140 kDa polypeptide DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA. +
SRF Serum response factor SRF is a transcription factor that binds to the serum response element (SRE) +