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Table 5 Analysis of predicted cancer genes in Table 4. Column "related to cancer" indicates whether literature [43] and information coming from UniProt [44], Reactome [45] and GO [46] indicate a strong involvement in cancer (++), somehow related to cancer (+) or not related to cancer (-). Literature references for each gene found to be involved in cancer are provided as additional file 8.

From: Predicting cancer involvement of genes from heterogeneous data

Gene name Description and Function/Pathway Related to cancer
CDK9 Cell division protein kinase 9
Regulation of progression through cell cycle
++
GATA2 Endothelial transcription factor GATA-2
Transcriptional activator which regulates endothelin-1 gene expression
+
ATF2 Cyclic AMP-dependent transcription factor ATF-2
Transcriptional activator which binds to the CRE, present in many viral and cellular promoters.
+
CCNB1 G2/mitotic-specific cyclin-B1
Essential for the control of the cell cycle at the G2/M (mitosis) transition.
++
CSNK2A2 Casein kinase II subunit alpha
Participates in Wnt signaling.
+
PPARBP Peroxisome proliferator-activated receptor-binding protein
Essential for embryogenesis. Plays a role in transcriptional coactivation
++
CSK Tyrosine-protein kinase CSK
Negative regulation of cell proliferation
++
KIN27 Protein kinase A-alpha
ATP binding and protein serine/threonine kinase activity
-
CUL1 Cullin-1
Mediates the ubiquitination of proteins involved in cell cycle progression, signal transduction and transcription
++
DKFZP686I18166 Hypothetical protein
ATP binding and protein kinase activity
-
STAT5B Signal transducer and activator of transcription 5B
Signal transduction and activation of transcription
++
MCM7 DNA replication licensing factor MCM7
Required for DNA replication and cell proliferation. Required for S-phase checkpoint activation upon UV-induced damage.
++
SURB7 Mediator of RNA polymerase II transcription subunit 21
Regulation of transcription.
-
MST1R Macrophage-stimulating protein receptor [Precursor]
Receptor for macrophage stimulating protein (MSP). Tyrosine-protein kinase activity.
++
KHDRBS1 KH domain-containing, RNA-binding, signal transduction-associated protein 1
Role in G2-M progression in the cell cycle.
++
SYK Tyrosine-protein kinase SYK
Positive effector of BCR-stimulated responses.
++
KDR Kinase insert domain receptor
Kinase activity and receptor activity.
++
NME2 Nucleoside diphosphate kinase B
Major role in the synthesis of nucleoside triphosphates other than ATP.
++
POLR2B DNA-directed RNA polymerase II 140 kDa polypeptide
DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA.
+
SRF Serum response factor
SRF is a transcription factor that binds to the serum response element (SRE)
+