Table 5 Analysis of predicted cancer genes in Table 4. Column "related to cancer" indicates whether literature [43] and information coming from UniProt [44], Reactome [45] and GO [46] indicate a strong involvement in cancer (++), somehow related to cancer (+) or not related to cancer (-). Literature references for each gene found to be involved in cancer are provided as additional file 8.
From: Predicting cancer involvement of genes from heterogeneous data
Gene name | Description and Function/Pathway | Related to cancer |
|---|---|---|
CDK9 | Cell division protein kinase 9 Regulation of progression through cell cycle | ++ |
GATA2 | Endothelial transcription factor GATA-2 Transcriptional activator which regulates endothelin-1 gene expression | + |
ATF2 | Cyclic AMP-dependent transcription factor ATF-2 Transcriptional activator which binds to the CRE, present in many viral and cellular promoters. | + |
CCNB1 | G2/mitotic-specific cyclin-B1 Essential for the control of the cell cycle at the G2/M (mitosis) transition. | ++ |
CSNK2A2 | Casein kinase II subunit alpha Participates in Wnt signaling. | + |
PPARBP | Peroxisome proliferator-activated receptor-binding protein Essential for embryogenesis. Plays a role in transcriptional coactivation | ++ |
CSK | Tyrosine-protein kinase CSK Negative regulation of cell proliferation | ++ |
KIN27 | Protein kinase A-alpha ATP binding and protein serine/threonine kinase activity | - |
CUL1 | Cullin-1 Mediates the ubiquitination of proteins involved in cell cycle progression, signal transduction and transcription | ++ |
DKFZP686I18166 | Hypothetical protein ATP binding and protein kinase activity | - |
STAT5B | Signal transducer and activator of transcription 5B Signal transduction and activation of transcription | ++ |
MCM7 | DNA replication licensing factor MCM7 Required for DNA replication and cell proliferation. Required for S-phase checkpoint activation upon UV-induced damage. | ++ |
SURB7 | Mediator of RNA polymerase II transcription subunit 21 Regulation of transcription. | - |
MST1R | Macrophage-stimulating protein receptor [Precursor] Receptor for macrophage stimulating protein (MSP). Tyrosine-protein kinase activity. | ++ |
KHDRBS1 | KH domain-containing, RNA-binding, signal transduction-associated protein 1 Role in G2-M progression in the cell cycle. | ++ |
SYK | Tyrosine-protein kinase SYK Positive effector of BCR-stimulated responses. | ++ |
KDR | Kinase insert domain receptor Kinase activity and receptor activity. | ++ |
NME2 | Nucleoside diphosphate kinase B Major role in the synthesis of nucleoside triphosphates other than ATP. | ++ |
POLR2B | DNA-directed RNA polymerase II 140 kDa polypeptide DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA. | + |
SRF | Serum response factor SRF is a transcription factor that binds to the serum response element (SRE) | + |