From: An efficient visualization tool for the analysis of protein mutation matrices
Antibody chain, Region | Mutation2 | Antigen | Affinity reduction | Reference |
---|---|---|---|---|
Light Chain, CDR | R66G | Carcinoembryonic antigen (CEA) | Four-fold (R) | 17 |
Light Chain, CDR | Y96V | Finrozole | > Ten-fold (R) | 18 |
Light Chain, CDR | Y96F | Atrazine | Two-fold (R) | 19 |
Heavy Chain, CDR | W33A | Finrozole, d-enantiomer | Five-fold (R) | 18 |
Heavy Chain, CDR | S52F | Digoxin | Two-fold (R) | 20 |
Heavy Chain, CDR | A71F | Tumor-associated glycoprotein 72 (TAG72) | 12-fold (R) | 21 |
Heavy Chain, CDR | K93I | TAG72 | 20-fold (R) | 21 |
Heavy Chain, FR | D72N | CD30 | Significantly decreased binding signal | 22 |
Heavy Chain, FR | K94N | HyHEL-10 | ~Ten-fold(R) | 23 |