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Table 4 Artificially-introduced mutations implicated in antibody affinity reduction

From: An efficient visualization tool for the analysis of protein mutation matrices

Antibody chain, Region

Mutation2

Antigen

Affinity reduction

Reference

Light Chain, CDR

R66G

Carcinoembryonic antigen (CEA)

Four-fold (R)

17

Light Chain, CDR

Y96V

Finrozole

> Ten-fold (R)

18

Light Chain, CDR

Y96F

Atrazine

Two-fold (R)

19

Heavy Chain, CDR

W33A

Finrozole, d-enantiomer

Five-fold (R)

18

Heavy Chain, CDR

S52F

Digoxin

Two-fold (R)

20

Heavy Chain, CDR

A71F

Tumor-associated glycoprotein 72 (TAG72)

12-fold (R)

21

Heavy Chain, CDR

K93I

TAG72

20-fold (R)

21

Heavy Chain, FR

D72N

CD30

Significantly decreased binding signal

22

Heavy Chain, FR

K94N

HyHEL-10

~Ten-fold(R)

23

  1. 2 Written in the form original residue, followed by the position (Kabat notation), then the replacement residue