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Figure 1 | BMC Bioinformatics

Figure 1

From: Aspects of coverage in medical DNA sequencing

Figure 1

Traditional haploid coverage model [15, 16] versus diploid medical sequencing coverage results for minimum number of covering reads φ {1, 2, 3, 4, 5}. The figure also shows an additional curve that replots the diploid φ = 2 curve, except where abscissa values are scaled by one-half. This aspect is relevant to the discussion of why the redundancies for φ = 1 and φ = 2 do not differ by a factor of two. Coverage progressions for φ {1, 2} are also shown for the recent Illumina resequencing of C. elegans by Hillier et al. [28]. These points represent average coverages over all chromosome pairs, while their error bars show the observed minima and maxima. Simulation data for φ = 1 on a 20 kb fragment using 250 bp reads [20] are also shown. Points and error bars represent the averages and extrema, respectively, of 250 simulations.

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