Mapping gene expression quantitative trait loci by singular value decomposition and independent component analysis

Table 1 Summary of single trait linkage analyses

Group	Bin: Chromosome, Coordinate	N	X/T	P-adj	Common GO Annotation
1	I: 52357	23	10/215	< 0.001	lipid/fatty acid metabolism
2	II: 368991	74	NA	NA	NA
3	II: 554641	514	80/213	< 0.001	ribosome biogenesis
4	II: 667104	99	22/213	< 0.001	cytoplasm organization and ribosome bio-genesis, rRNA processing
5	III: 90986	265	49/99	< 0.001	amino acid biosynthesis
6	III: 201166	53	5/8	< 0.001	regulation of transcription, mating-type specific
7	V: 116389	40	3/13	< 0.001	pyrimidine base biosynthesis
8	V: 422588	287	44/171	< 0.001	cytosolic ribosome
9	VII: 55461	42	10/252	0.001	cytoplasm organization and ribosome bio-genesis
10	VIII: 111679	153	18/100	< 0.001	conjugation, response to pheromone
11	X: 329085	21	NA	NA	NA
12	XII: 671271	182	24/45	< 0.001	ergosterol/sterol metabolism
13	XII: 1051813	44	15/84	< 0.001	helicase activity, telomerase maintenance
14	XIII: 49969	65	3/5	0.008	serine family amino acid metabolism
15	XIV: 486861	511	61/83	< 0.001	mitochondrial ribosome
16	XV: 172654	458	37/218	< 0.001	carbohydrate metabolism
17	XV: 563943	38	18/46	< 0.001	oxidative phosphorylation/respiratory- chain phosphorylation

eQTL positions of the 5013 traits for which linkage was detected at an FDR cutoff of 0.05, were binned into 20 kb bins and the chromosomal coordinates of each linkage hotspots that have more eQTLs than expected by chance, the number of traits linking to the hotspot (N), the number of those traits that have the over-represented GO attribute (X), the total number of traits that have this attribute (T) and over-represented GO annotation terms are reported.

ISSN: 1471-2105