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Table 3 Summary of ICAtrait linkage and Gene Ontology analyses

From: Mapping gene expression quantitative trait loci by singular value decomposition and independent component analysis

Trait QTL N X/T P-adj GO over-representation
1 XII: 423789, XV: 179409 189 58/1017 < 0.001 mitochondrion
2 III: 201166 45 5/8 < 0.001 mating-type specific/mating-type specific transcriptional control
3 0 77 26/108 < 0.001 nitrogen compound biosynthesis, amine biosynthesis
4 XII: 473036 12 4/5 < 0.001 asparagine catabolism
5 0 3 NA NA NA
6 II: 554641 1448 54/83 < 0.001 mitochondrial ribosome
7 V: 422588 63 26/94 < 0.001 retrotransposon nucleocapsid/VLP/Virus-like particle
8 III: 90986 49 8/13 < 0.001 nitrogen compound biosynthesis, amine biosynthesis
9 X: 329085 22 4/6 < 0.001 alcohol dehydrogenase activity/alcohol dehydrogenase (NAD) activity, fermentation
10 XIV: 449639 304 225/1017 < 0.001 mitochondrion, mitochondrial ribosome
11 XII: 660992 83 22/37 < 0.001 sterol metabolism, sterol biosynthesis
12 V: 116389 9 3/13 < 0.001 pyrimidine base biosynthesis
13 XV: 563943 184 125/1017 < 0.001 oxidative phosphorylation/respiratory- chain phosphorylation, mitochondrion
14 VIII: 111686 42 16/100 < 0.001 conjugation, sexual reproduction
15 IX: 141014 XIII: 395391 8 NA NA NA
16 IV: 1501558, XI: 298361, 47 15/84 < 0.001 helicase activity, telomerase-independent
  XII: 824230, XII: 1056097     telomere maintenance
17 IV: 527484 6 3/3 < 0.001 sodium ion transport/sodium transport/sodium:solute transport
18 XII: 423789, XV: 179409 32 2/2 0.015 NA
19 XIII: 40447 14 4/5 < 0.001 acid phosphatase activity
20 0 63 NA NA NA
  1. For each ICAtrait, we report the number and position of any significant linkages detected, the number of traits that are significantly correlated with a specific ICAtrait (N), the number of correlated traits that have the over-represented GO attribute (X), the total number of traits that have this attribute (T) and also the over-represented GO annotation term. Three of the 20 show no over-representation of biological functions while for remaining 16 both previously described and novel GO categories with associated eQTL were detected. Analysis of ICAtrait 7 and 9 are described in more detail in the text.