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Table 3 Summary of ICAtrait linkage and Gene Ontology analyses

From: Mapping gene expression quantitative trait loci by singular value decomposition and independent component analysis

Trait

QTL

N

X/T

P-adj

GO over-representation

1

XII: 423789, XV: 179409

189

58/1017

< 0.001

mitochondrion

2

III: 201166

45

5/8

< 0.001

mating-type specific/mating-type specific transcriptional control

3

0

77

26/108

< 0.001

nitrogen compound biosynthesis, amine biosynthesis

4

XII: 473036

12

4/5

< 0.001

asparagine catabolism

5

0

3

NA

NA

NA

6

II: 554641

1448

54/83

< 0.001

mitochondrial ribosome

7

V: 422588

63

26/94

< 0.001

retrotransposon nucleocapsid/VLP/Virus-like particle

8

III: 90986

49

8/13

< 0.001

nitrogen compound biosynthesis, amine biosynthesis

9

X: 329085

22

4/6

< 0.001

alcohol dehydrogenase activity/alcohol dehydrogenase (NAD) activity, fermentation

10

XIV: 449639

304

225/1017

< 0.001

mitochondrion, mitochondrial ribosome

11

XII: 660992

83

22/37

< 0.001

sterol metabolism, sterol biosynthesis

12

V: 116389

9

3/13

< 0.001

pyrimidine base biosynthesis

13

XV: 563943

184

125/1017

< 0.001

oxidative phosphorylation/respiratory- chain phosphorylation, mitochondrion

14

VIII: 111686

42

16/100

< 0.001

conjugation, sexual reproduction

15

IX: 141014 XIII: 395391

8

NA

NA

NA

16

IV: 1501558, XI: 298361,

47

15/84

< 0.001

helicase activity, telomerase-independent

 

XII: 824230, XII: 1056097

   

telomere maintenance

17

IV: 527484

6

3/3

< 0.001

sodium ion transport/sodium transport/sodium:solute transport

18

XII: 423789, XV: 179409

32

2/2

0.015

NA

19

XIII: 40447

14

4/5

< 0.001

acid phosphatase activity

20

0

63

NA

NA

NA

  1. For each ICAtrait, we report the number and position of any significant linkages detected, the number of traits that are significantly correlated with a specific ICAtrait (N), the number of correlated traits that have the over-represented GO attribute (X), the total number of traits that have this attribute (T) and also the over-represented GO annotation term. Three of the 20 show no over-representation of biological functions while for remaining 16 both previously described and novel GO categories with associated eQTL were detected. Analysis of ICAtrait 7 and 9 are described in more detail in the text.