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Table 3 Area under ROC curve (AUC), sensitivity (Sn) and specificity (Sp) values for Predikin and five comparable methods

From: Predikin and PredikinDB: a computational framework for the prediction of protein kinase peptide specificity and an associated database of phosphorylation sites

  Ser/Thr CMGC Tyr
Method AUC Sn % Sp % AUC Sn % Sp % AUC Sn % Sp %
SDR 1,2 0.86 (0.04) 75.5 (9.2) 86.6 (7.2) 0.93 (0.02) 89.4 (2.9) 91.3 (2.1) n/a n/a n/a
KSD 2 0.86 (0.05) 73.7 (10.1) 90.0 (9.3) 0.88 (0.02) 83.8 (3.5) 94.1 (1.1) 0.76 (0.07) 73.0 (13.3) 79.7 (17.9)
PANTHER 2 0.88 (0.04) 74.6 (5.0) 94.2 (1.8) 0.91 (0.03) 85.5 (6.4) 93.4 (2.1) 0.66 (0.09) 61.0 (5.5) 79.9 (13.8)
GPS 0.83 76.0 87.2 0.94 97.8 89.8 0.72 56.0 88.2
KinasePhos 0.78 52.9 92.5 0.95 90.8 86.6 0.89 80.0 85.1
NetPhosK 0.90 86.3 78.8 0.57 16.8 95.4 0.68 60.0 71.4
PPSP 0.92 92.2 83.6 0.95 97.8 89.5 0.81 60.0 98.1
Scansite 0.95 86.3 93.3 0.94 94.6 87.8 0.70 64.0 93.2
  1. 1SDR method not applicable to Tyr kinases
  2. 2AUC, sensitivity and specificity values are the mean and standard deviation (in parentheses) of 10 cross-validation tests