Figure 2
From: Prediction of enzyme function by combining sequence similarity and protein interactions
a Relative improvement over PSI-BLAST as a function of the parameters used (Methods). b ROC curves obtained for PSI-BLAST and ModFun, using different expansion and filter cutoffs (solid line, PSI-BLAST; filled circles, ModFun with expansion cutoff of 40% and filter cutoff of 55%; empty circles, ModFun with expansion cutoff of 50% and filter cutoff of 55%; stars, ModFun without expansion nor filter). Labels in the plot indicate specificity and sensitivity at the 40% identity threshold for PSI-BLAST and ModFun with optimal parameters (expansion cutoff of 40%, filter cutoff of 55%).