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Table 1 Genotype distribution at each marker locus: wild type (WT); heterozygous type (Hetero); homozygous type (Homo).

From: New application of intelligent agents in sporadic amyotrophic lateral sclerosis identifies unexpected specific genetic background

  

Cases: 54

Controls: 208

  
  

Frequency

     
 

rs number

WT

Homo

Hetero

WT

Homo

Hetero

f (A)

f (a)

LPA 93 C/T

rs1853021

45

0

9

161

6

41

0,872596

0,127404

LPA 121 G/A

rs1800769

33

1

20

166

3

39

0,891827

0,108173

APOA4 thr347ser

rs675

32

1

21

135

8

65

0,805288

0,194712

APOA4 gln360his

rs5110

44

0

10

183

1

24

0,9375

0,0625

APOB thr71ile

rs1367117

35

5

14

100

20

88

0,692308

0,307692

APOC3 -641C/A

rs2542052

17

6

31

74

21

113

0,627404

0,372596

APOC3 -482 C/T

rs2854117

23

2

29

104

13

91

0,71875

0,28125

APOC3 -455 T/C

rs2854116

16

7

31

74

24

110

0,620192

0,379808

APOC3 1100 C/T

rs4520

30

3

21

104

24

80

0,692308

0,307692

APOC3 3175 C/G

rs5128

47

1

6

170

2

36

0,903846

0,096154

APOC3 3206 T/G

rs4225

21

13

20

72

37

99

0,584135

0,415865

APOE cys112arg

rs429358

49

0

5

175

1

32

0,918269

0,081731

APOE arg158cys

rs7412

45

1

8

186

1

21

0,944712

0,055288

ADRB3 trp64arg

rs4994

45

0

9

185

0

23

0,944712

0,055288

PPAR pro12ala

rs1801282

48

0

6

170

1

37

0,90625

0,09375

LIPC -480 C/T

rs1800588

29

9

16

146

11

51

0,824519

0,175481

LPL -93 T/G

rs1800590

54

0

0

201

0

7

0,983173

0,016827

LPL asp9asn

rs1801177

54

0

0

201

0

7

0,983173

0,016827

LPL asn291ser

rs268

53

0

1

202

0

6

0,985577

0,014423

LPL ser447term

rs328

47

0

7

164

3

41

0,887019

0,112981

PON1 met55leu

rs854560

2

19

33

31

84

93

0,372596

0,627404

PON1 gln192arg

rs662

26

10

18

102

26

80

0,682692

0,317308

PON2 ser311cys

rs6954345

33

2

19

131

6

71

0,800481

0,199519

LDLR NcoI +/-

rs5742911

28

5

21

98

19

91

0,689904

0,310096

CETP -631 C/A

rs1800776

45

0

9

168

2

38

0,899038

0,100962

CETP -629 C/A

rs1800775

6

16

32

49

60

99

0,473558

0,526442

CETP ile405val

rs5882

20

9

25

86

30

92

0,634615

0,365385

TNFbeta thr26asn

rs1041981

31

7

16

113

12

83

0,742788

0,257212

MTHFR 677 C/T

rs1801133

19

12

23

60

35

113

0,560096

0,439904

NOS3 -922 A/G

rs1800779

9

11

34

57

52

99

0,512019

0,487981

NOS3 -690 C/T

rs3918226

40

2

12

164

3

41

0,887019

0,112981

NOS3 glu298asp

rs1799983

18

11

25

75

36

97

0,59375

0,40625

DCP1 IVS16 ins/del

rs1799752

24

8

22

38

70

100

0,423077

0,576923

AGTR1 1166 A/C

rs5186

31

5

18

99

10

99

0,713942

0,286058

AGT met235thr

rs699

14

4

36

67

46

95

0,550481

0,449519

NPPA 664 G/A

rs5063

52

0

2

194

0

14

0,966346

0,033654

NPPA 2238 T/C

rs5065

31

3

20

149

3

56

0,850962

0,149038

ADD1 gly460trp

rs4961

36

3

15

145

4

59

0,838942

0,161058

SCNN1A trp493arg

rs5742912

54

0

0

186

0

22

0,947115

0,052885

SCNN1A ala663thr

rs2228576

27

3

24

94

18

96

0,682692

0,317308

GNB3 825 C/T

rs5443

30

5

19

103

19

86

0,701923

0,298077

ADRB2 arg16gly

rs1042713

11

21

22

31

84

93

0,372596

0,627404

ADRB2 gln27glu

rs1042714

24

7

23

89

22

97

0,661058

0,338942

MMP3(-1171) 5A/6A

rs3025058

9

14

31

34

59

115

0,439904

0,560096

FII 20210 G/A

rs1799963

53

0

1

200

0

8

0,980769

0,019231

FV arg506gln

rs6025

53

0

1

204

0

4

0,990385

0,009615

FVII del/ins

rs5742910

41

1

12

144

4

60

0,836538

0,163462

FVII arg353gln

rs6046

40

1

13

152

3

53

0,858173

0,141827

PAI (-675) 5G/4G

rs1799768

8

21

25

40

52

116

0,471154

0,528846

PAI 11053 G/T

rs7242

13

12

29

39

66

103

0,435096

0,564904

FGB -455 G/A

rs1800790

34

2

18

121

8

79

0,771635

0,228365

ITGA2 873 G/A

rs1062535

22

7

25

72

27

109

0,608173

0,391827

ITGB3 leu33pro

rs5918

37

1

16

159

6

43

0,867788

0,132212

SELE ser128arg

rs5361

45

0

9

168

2

38

0,899038

0,100962

SELE leu554phe

rs5355

47

0

7

180

1

27

0,930288

0,069712

ICAM gly214arg

rs1799969

54

0

0

171

0

37

0,911058

0,088942

TNF alpha-376 G/A

rs1800750

51

0

3

204

0

4

0,990385

0,009615

TNF alpha-308 G/A

rs1800629

44

0

10

158

1

49

0,877404

0,122596

TNF alpha-244 G/A

rs673

54

0

0

207

0

1

0,997596

0,002404

TNF alpha-238 G/A

rs361525

52

0

2

192

0

16

0,961538

0,038462

  1. Deviations of the genotype frequencies from the Hardy-Weinberg equilibrium were tested in the control group with chi-squared statistics (p values ranging from 0.2 to 1.0). Allele frequencies at each marker locus were calculated from the genotype frequencies of the control group under the null hypothesis of Hardy-Weinberg equilibrium. Allele frequencies at each marker locus are reported.