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Table 1 Genotype distribution at each marker locus: wild type (WT); heterozygous type (Hetero); homozygous type (Homo).

From: New application of intelligent agents in sporadic amyotrophic lateral sclerosis identifies unexpected specific genetic background

   Cases: 54 Controls: 208   
   Frequency      
  rs number WT Homo Hetero WT Homo Hetero f (A) f (a)
LPA 93 C/T rs1853021 45 0 9 161 6 41 0,872596 0,127404
LPA 121 G/A rs1800769 33 1 20 166 3 39 0,891827 0,108173
APOA4 thr347ser rs675 32 1 21 135 8 65 0,805288 0,194712
APOA4 gln360his rs5110 44 0 10 183 1 24 0,9375 0,0625
APOB thr71ile rs1367117 35 5 14 100 20 88 0,692308 0,307692
APOC3 -641C/A rs2542052 17 6 31 74 21 113 0,627404 0,372596
APOC3 -482 C/T rs2854117 23 2 29 104 13 91 0,71875 0,28125
APOC3 -455 T/C rs2854116 16 7 31 74 24 110 0,620192 0,379808
APOC3 1100 C/T rs4520 30 3 21 104 24 80 0,692308 0,307692
APOC3 3175 C/G rs5128 47 1 6 170 2 36 0,903846 0,096154
APOC3 3206 T/G rs4225 21 13 20 72 37 99 0,584135 0,415865
APOE cys112arg rs429358 49 0 5 175 1 32 0,918269 0,081731
APOE arg158cys rs7412 45 1 8 186 1 21 0,944712 0,055288
ADRB3 trp64arg rs4994 45 0 9 185 0 23 0,944712 0,055288
PPAR pro12ala rs1801282 48 0 6 170 1 37 0,90625 0,09375
LIPC -480 C/T rs1800588 29 9 16 146 11 51 0,824519 0,175481
LPL -93 T/G rs1800590 54 0 0 201 0 7 0,983173 0,016827
LPL asp9asn rs1801177 54 0 0 201 0 7 0,983173 0,016827
LPL asn291ser rs268 53 0 1 202 0 6 0,985577 0,014423
LPL ser447term rs328 47 0 7 164 3 41 0,887019 0,112981
PON1 met55leu rs854560 2 19 33 31 84 93 0,372596 0,627404
PON1 gln192arg rs662 26 10 18 102 26 80 0,682692 0,317308
PON2 ser311cys rs6954345 33 2 19 131 6 71 0,800481 0,199519
LDLR NcoI +/- rs5742911 28 5 21 98 19 91 0,689904 0,310096
CETP -631 C/A rs1800776 45 0 9 168 2 38 0,899038 0,100962
CETP -629 C/A rs1800775 6 16 32 49 60 99 0,473558 0,526442
CETP ile405val rs5882 20 9 25 86 30 92 0,634615 0,365385
TNFbeta thr26asn rs1041981 31 7 16 113 12 83 0,742788 0,257212
MTHFR 677 C/T rs1801133 19 12 23 60 35 113 0,560096 0,439904
NOS3 -922 A/G rs1800779 9 11 34 57 52 99 0,512019 0,487981
NOS3 -690 C/T rs3918226 40 2 12 164 3 41 0,887019 0,112981
NOS3 glu298asp rs1799983 18 11 25 75 36 97 0,59375 0,40625
DCP1 IVS16 ins/del rs1799752 24 8 22 38 70 100 0,423077 0,576923
AGTR1 1166 A/C rs5186 31 5 18 99 10 99 0,713942 0,286058
AGT met235thr rs699 14 4 36 67 46 95 0,550481 0,449519
NPPA 664 G/A rs5063 52 0 2 194 0 14 0,966346 0,033654
NPPA 2238 T/C rs5065 31 3 20 149 3 56 0,850962 0,149038
ADD1 gly460trp rs4961 36 3 15 145 4 59 0,838942 0,161058
SCNN1A trp493arg rs5742912 54 0 0 186 0 22 0,947115 0,052885
SCNN1A ala663thr rs2228576 27 3 24 94 18 96 0,682692 0,317308
GNB3 825 C/T rs5443 30 5 19 103 19 86 0,701923 0,298077
ADRB2 arg16gly rs1042713 11 21 22 31 84 93 0,372596 0,627404
ADRB2 gln27glu rs1042714 24 7 23 89 22 97 0,661058 0,338942
MMP3(-1171) 5A/6A rs3025058 9 14 31 34 59 115 0,439904 0,560096
FII 20210 G/A rs1799963 53 0 1 200 0 8 0,980769 0,019231
FV arg506gln rs6025 53 0 1 204 0 4 0,990385 0,009615
FVII del/ins rs5742910 41 1 12 144 4 60 0,836538 0,163462
FVII arg353gln rs6046 40 1 13 152 3 53 0,858173 0,141827
PAI (-675) 5G/4G rs1799768 8 21 25 40 52 116 0,471154 0,528846
PAI 11053 G/T rs7242 13 12 29 39 66 103 0,435096 0,564904
FGB -455 G/A rs1800790 34 2 18 121 8 79 0,771635 0,228365
ITGA2 873 G/A rs1062535 22 7 25 72 27 109 0,608173 0,391827
ITGB3 leu33pro rs5918 37 1 16 159 6 43 0,867788 0,132212
SELE ser128arg rs5361 45 0 9 168 2 38 0,899038 0,100962
SELE leu554phe rs5355 47 0 7 180 1 27 0,930288 0,069712
ICAM gly214arg rs1799969 54 0 0 171 0 37 0,911058 0,088942
TNF alpha-376 G/A rs1800750 51 0 3 204 0 4 0,990385 0,009615
TNF alpha-308 G/A rs1800629 44 0 10 158 1 49 0,877404 0,122596
TNF alpha-244 G/A rs673 54 0 0 207 0 1 0,997596 0,002404
TNF alpha-238 G/A rs361525 52 0 2 192 0 16 0,961538 0,038462
  1. Deviations of the genotype frequencies from the Hardy-Weinberg equilibrium were tested in the control group with chi-squared statistics (p values ranging from 0.2 to 1.0). Allele frequencies at each marker locus were calculated from the genotype frequencies of the control group under the null hypothesis of Hardy-Weinberg equilibrium. Allele frequencies at each marker locus are reported.