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Table 1 Block Design Example

From: poolHiTS: A Shifted Transversal Design based pooling strategy for high-throughput drug screening

Number of blocks (B) Number of compounds per block (n B ) Number of active compounds expected per block (d B ) Number of tests needed per block (t B ) Actual error-rate handled (e) Actual mixing constraint (m) Total number of tests needed (t)
1 10000 3 - - - -
25 400 1 492 1.02% 10 12300
50 200 1 92 1.09% 9 4600
77 130 1 52 1.92% 10 4004
91 110 1 44 2.27% 10 4004
100 100 1 44 2.27% 10 4400
500 20 1 20 5% 4 10000
  1. Sample case of n = 10, 000, d = 3, e = 1% and m = 10 showing the efficiency of selected block design parameters. The choice of error-rate (e = 1%) does not permit a full library design (first row), thus it is left empty.