Table 2 Residues involved in main functional interhelical interactions in GPR17

TM1

D41-R87*

D41-D77*

N49-D77

Y38-S287

N310-R58

E30-R280

D41-S287

D41-N289*

N49-N289

N49-Y297*

N49-G290

TM2

T107-T86

D77-N114

H72-W156

R87-S287

D77-Y297*

D77-N289

D77-D293

D77-G290

N67-K303*

TM3

D128-R129

T123-T208

Y116-A162

S126-Y212

T123-T208

Y116-S196

Y112-H252

S118-N289

TM6

C247-T286

Y251-T286

TM7

D293-N289

Y297-K303*

Main inter-helical networks

Residues involved in H-bonds/ionic interactions

TM1-TM2-TM7

N49-D77-G290

TM1-TM2-TM3

N49-D77-N114

TM1-TM2-TM7

N49-D77-N289