Table 1 Amyloid families in AMYPdb

Alpha Fibrinogen

Involved in the coagulation cascade

Autosomal dominant hereditary hepatic or renal amyloidosis

59

3

1

Alpha Synuclein

Unknown

Synucleopathies, such as Alzheimer's and Parkinson's diseases

21

85

0

Amyloid Beta Precursor

Protease inhibitor

Alzheimer's disease and aged Down's syndrome

125

108

3

Apolipoprotein A-1

Lipid metabolism

Autosomal dominant systemic amyloidosis

54

16

0

Atrial Natriuretic Factor

Blood pressure and sodium balance

Isolated Atrial Amyloid

34

5

1

Beta-2 Microglobulin

Class 1 human leukocyte antigen

Aggregation in the musculoskeletal system

141

0

1

Bri2

Unknown

Familial British Dementia (FBD)

3

*

0

C-Protein

Major component of lung surfactant

Pulmonary alveolar proteinosis

16

7

1+

Calcitonin

Polypeptidic hormone

Amyloid deposits in case of medullary thyroid cancer

37

16

1

Cystatin C

Cystein protease inhibitor

Alzheimer's disease and cerebral amyloid angiopathy

67

0

1

Gelsolin

Modulation of actin filament length

Gelsolin familial amyloidosis

39

18

0

Huntingtin

Fast axonal trafficking

Huntington's disease

19

109

0

Immunoglobulins

Immune response

Light-chain amyloidosis

0

*

0

Insulin

Metabolism of carbohydrates and fat

Localized amyloidosis at injection sites of type 1 diabetic patients

160

3

1

Islet Amyloid Polypeptide

Glycaemia regulation

Aggregates in pancreatic islets of type 2 diabetes and insulinomas

17

82

1

Lactadherin

Anticoagulant?

Aortic medial amyloidoses

5

*

3

Lactoferrin

Transferrin

Amyloid deposits in the cornea, seminal vesicles and brain

34

94

3

Lysozyme

Bacteriolytic enzyme

Non-neuropathic systemic amyloidosis

122

30

1

Microcin E492

Bacterial bacteriocine

Regulation of the protein's activity

2

*

0

Parkin

Proteasomal degradation?

Parkinson's disease

16

*

0

Prolactin

Hormone secreted by the pituitary gland

Amyloid deposits in pituitary glands of aging individuals

112

54

2

Serpin

Serine protease inhibitors

Serpinopathy

3

*

0

Serum amyloid A

Cell adhesion, migration, and proliferation

Inflammation-associated reactive amyloidosis

74

63

1+

Tau

Microtubule assembly and stability

Alzheimer's disease and dementias

37

13

1

Transthyretin

Thyroxine transport

Familial amyloid polyneuropathies

54

97

1+

Het-S

Heterocaryon incompatibility

Prionization involved in the protein's normal function

1

*

0

New 1

Unknown

No stable prion has been shown in vivo

2

*

0

Prion Protein (PrP)

Signal transmission, copper regulation?

Transmissible spongiform encephalopathies and dementias

353

6

2+

Rnq 1

Unknown

Unknown

1

*

0

Sup35

Translation termination factor

Prionization might be advantageous in stress conditions

82

48

1

Ure2

Nitrogen metabolism

Loss of Ure2 function

15

99

0