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Table 1 Amyloid families in AMYPdb

From: AMYPdb: A database dedicated to amyloid precursor proteins

Family Function Pathology S A P
Alpha Fibrinogen Involved in the coagulation cascade Autosomal dominant hereditary hepatic or renal amyloidosis 59 3 1
Alpha Synuclein Unknown Synucleopathies, such as Alzheimer's and Parkinson's diseases 21 85 0
Amyloid Beta Precursor Protease inhibitor Alzheimer's disease and aged Down's syndrome 125 108 3
Apolipoprotein A-1 Lipid metabolism Autosomal dominant systemic amyloidosis 54 16 0
Atrial Natriuretic Factor Blood pressure and sodium balance Isolated Atrial Amyloid 34 5 1
Beta-2 Microglobulin Class 1 human leukocyte antigen Aggregation in the musculoskeletal system 141 0 1
Bri2 Unknown Familial British Dementia (FBD) 3 * 0
C-Protein Major component of lung surfactant Pulmonary alveolar proteinosis 16 7 1+
Calcitonin Polypeptidic hormone Amyloid deposits in case of medullary thyroid cancer 37 16 1
Cystatin C Cystein protease inhibitor Alzheimer's disease and cerebral amyloid angiopathy 67 0 1
Gelsolin Modulation of actin filament length Gelsolin familial amyloidosis 39 18 0
Huntingtin Fast axonal trafficking Huntington's disease 19 109 0
Immunoglobulins Immune response Light-chain amyloidosis 0 * 0
Insulin Metabolism of carbohydrates and fat Localized amyloidosis at injection sites of type 1 diabetic patients 160 3 1
Islet Amyloid Polypeptide Glycaemia regulation Aggregates in pancreatic islets of type 2 diabetes and insulinomas 17 82 1
Lactadherin Anticoagulant? Aortic medial amyloidoses 5 * 3
Lactoferrin Transferrin Amyloid deposits in the cornea, seminal vesicles and brain 34 94 3
Lysozyme Bacteriolytic enzyme Non-neuropathic systemic amyloidosis 122 30 1
Microcin E492 Bacterial bacteriocine Regulation of the protein's activity 2 * 0
Parkin Proteasomal degradation? Parkinson's disease 16 * 0
Prolactin Hormone secreted by the pituitary gland Amyloid deposits in pituitary glands of aging individuals 112 54 2
Serpin Serine protease inhibitors Serpinopathy 3 * 0
Serum amyloid A Cell adhesion, migration, and proliferation Inflammation-associated reactive amyloidosis 74 63 1+
Tau Microtubule assembly and stability Alzheimer's disease and dementias 37 13 1
Transthyretin Thyroxine transport Familial amyloid polyneuropathies 54 97 1+
Het-S Heterocaryon incompatibility Prionization involved in the protein's normal function 1 * 0
New 1 Unknown No stable prion has been shown in vivo 2 * 0
Prion Protein (PrP) Signal transmission, copper regulation? Transmissible spongiform encephalopathies and dementias 353 6 2+
Rnq 1 Unknown Unknown 1 * 0
Sup35 Translation termination factor Prionization might be advantageous in stress conditions 82 48 1
Ure2 Nitrogen metabolism Loss of Ure2 function 15 99 0
  1. The six last lines of the table show the prion families. S, sequences in AMYPdb (full length and fragments); A, AMYPdb patterns with CF ≥ 0.9; *, not submitted to pattern discovery method; P, PROSITE super family signatures; P+, PROSITE family signatures.