Cluster | Subcluster | Characteristic | Biological Concepts (Up) | Biological Concepts (Down) |
---|---|---|---|---|
1 | overall | Atrophy | - | Cyclins |
1 | 1A | Atrophy – PABPN1 overexpression | Amino acyl tRNA synthetases, spermidine, polyamines, spermine, eukaryotic initiation factors | Platelet-derived growth factor, transforming growth factor-beta, insulin-like growth factor binding proteins |
1 | 1B | EOM-specific | Adipocytes, acyl CoA dehydrogenase | Cyclins, keratin, cyclin-dependent kinases |
2 | overall | Dystrophy/myositis | Troponin, matrix metalloproteases | Mitogen activated protein kinases, insulin, ERK1 acitivity, phosphorylation |
2 | 2A | Dystrophin defiency in EOM muscle | Troponin | - |
2 | 2B | Myositis | Chemokine, chemokine receptor | - |
2 | 2C | Regeneration | T-lymphocyte, phosphotransferases, phosphorylation, mitogen-activated protein kinases, integrins, cell cycle | Cullin proteins, mitogen-activated protein kinases, ligase |
2 | 2D | Differentiation | Troponin, tropomyosin, nemaline myopathies, sarcomeres, myosin heavy chain, calsequestrin | Inhibitor of differentiation proteins, E2F transcription factors, proteoglycan, cell cycle proteins |
2 | 2E | Ky-mutant/diverse | Leptin, desaturase, myosin heavy chains, neural cell adhesion molecules | Mitogen-activated protein kinases |
3 | overall | Ageing | Heterogeneous nuclear ribonucleoproteins, protein sumoylation, small nuclear ribonucleoprotein | - |