Figure 9

Experimental and randomized histogram and profile for the function hmm.mfs_1 for the Baev data set. Top panel: A density measure that is evaluated for each data point is given by the number of neighbors that are close according to a product similarity measure. The blue bars in the histograms represent the sum of all these densities. Those vector pairs are expected to be most relevant that exhibit a large absolute value of differential expression and a small angle between vectors. The white bars show the randomly distributed vectors that are expected to have some neighbors as well. Subsets of genes that have the same number of elements as the protein function under consideration were randomly selected. The histogram was constructed for this random subset. The process was repeated multiple times and averaged over 20 runs. Bottom panel: Gene expression profile for the function hmm.mfs_1. Profiles were obtained for all those genes in the functional group of hmm.mfs_1 that have a larger number of points in the neighborhood than any of the points in the histograms for the random subset (tails in the histograms). The individual genes that form this group are indicated in the inserted figure legends. The numbers on the x-axis symbolize the individual two-component systems. The order of two-component systems (attributes) is identical to Fig. 5.