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Figure 2 | BMC Bioinformatics

Figure 2

From: Extending pathways based on gene lists using InterPro domain signatures

Figure 2

Pathway classification. Simulated classification of KEGG pathways based on a binomial similarity measure. a) Single pathway (hsa04650, natural killer cell mediated cytotoxicity). The red curve shows the similarity to the pathway for increasing numbers of sampled pathway genes. The blue curve shows the similarity to the pathway for increasing numbers of random genes. Each point comprises an average from 1000 independent samples and the sampling variance indicated by the error bars is negligible. b) Results for all 181 KEGG pathways. The boxplots show AUC values indicating the amount of separation between 1,000 random sampled gene lists and lists containing pathway genes for all pathways, again sampling increasing numbers of genes.

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