MAID : An effect size based model for microarray data integration across laboratories and platforms

BMC Bioinformatics

Table 4 Top five over-represented GO biological process categories obtained with three different integartion models

GO (BP) categories	P values	# of genes
MAID
organismal physiological process	8.90E-007	41
immune response	4.96E-006	24
response to biotic stimulus	1.41E-005	25
defense response	1.81E-005	24
response to stimulus	1.98E-004	39
Rhodes et al.
response to biotic stimulus	8.12E-006	11
immune response	1.84E-005	10
response to pest, pathogen or parasite	2.12E-005	8
response to other organism	2.54E-005	8
defense response	3.54E-005	10
Parmigiani et al.
glyoxylate metabolism	4.44E-003	1
sphingolipid catabolism	4.44E-003	1
sphingomyelin metabolism	4.44E-003	1
sphingomyelin catabolism	4.44E-003	1
coagulation	8.37E-003	2

Top five enriched GO categories obtained with, MAID, Rhodes et al., and, Parmigiani et al. In each case genes had to be up (or down) regulated |fold| ≥ 1.5 in HCV samples compared to Normal with an expected number of false positives E(F P) = 10 for each gene list.

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