Table 1 The 31 informative physicochemical properties mined by IPMA.

NADH010102

Hydropathy scale based on self-information values in the two-state model of 9% accessibility

31.79

BROC820102

Retention coefficient in HFBA

29.80

MEIH800102

Average reduced distance for side chain

28.48

LEVM780101

Normalized frequency of alpha-helix, with weights

25.17

GUYH850104

Apparent partition energies calculated from Janin index

23.84

CORJ870101

NNEIG index

23.18

RACS770102

Average reduced distance for side chain

22.52

GEOR030108

Linker propensity from helical (annotated by DSSP) dataset

22.52

HARY940101

Mean volumes of residues buried in protein interiors

21.85

GRAR740102

Polarity

19.87

GUYH850105

Apparent partition energies calculated from Chothia index

19.87

MEIH800103

Average side chain orientation angle

17.88

KRIW790102

Fraction of site occupied by water

17.88

LEVM780106

Normalized frequency of reverse turn, unweighted

14.57

BULH740102

Apparent partial specific volume

13.25

FAUJ880101

Graph shape index

11.92

PUNT030102

Knowledge-based membrane-propensity scale from 3D_Helix in MPtopo databases

10.60

HUTJ700103

Entropy of formation

9.93

EISD840101

Consensus normalized hydrophobicity scale

8.61

CEDJ970105

Composition of amino acids in nuclear proteins (percent)

7.28

ZIMJ680102

Bulkiness

7.28

CEDJ970103

Composition of amino acids in membrane proteins (percent)

5.96

CHOC760103

Proportion of residues 95% buried

5.30

CEDJ970102

Composition of amino acids in anchored proteins (percent)

5.30

ROSM880102

Side chain hydropathy, corrected for solvation

4.64

BROC820101

Retention coefficient in TFA

4.64

FAUJ830101

Hydrophobic parameter pi

1.99

NAKH920101

AA composition of CYT of single-spanning proteins

1.99

ZHOH040102

The relative stability scale extracted from mutation experiments

1.99

NAKH900101

AA composition of total proteins

1.32

QIAN880129

Weights for coil at the window position of -4

1.32