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Table 1 Results of gene selection process

From: Function2Gene: A gene selection tool to increase the power of genetic association studies by utilizing public databases and expert knowledge

Keyword

GeneCards

Harvester

NCBI

Total Unique

12q24

355 (90)

217 (6)

276 (25)

391 (337)

16q12

108 (50)

34 (1)

65 (9)

118 (101)

1q23

251 (125)

94 (11)

135 (29)

295 (224)

1q25

144 (65)

50 (3)

94 (20)

167 (117)

1q31

96 (42)

32 (3)

58 (7)

106 (60)

1q41

69 (28)

23 (2)

54 (13)

85 (42)

1q42

212 (66)

107 (6)

153 (22)

241 (190)

2q35

107 (40)

39 (2)

75 (9)

120 (62)

2q36

92 (30)

50 (4)

53 (6)

104 (47)

2q37

217 (62)

97 (4)

156 (12)

233 (197)

4p15

100 (40)

40 (1)

68 (8)

110 (77)

4p16

219 (72)

114 (11)

165 (23)

257 (215)

6p11

19 (12)

6 (2)

9 (1)

23 (15)

6p12

114 (48)

44 (3)

82 (18)

136 (82)

6p21

749 (162)

321 (23)

597 (31)

809 (584)

adhesion

918 (428)

711 (221)

-

1139 (575)

antigen

712 (298)

787 (373)

-

1085 (0)

apoptosis

1013 (555)

682 (224)

-

1237 (564)

chemokine

168 (95)

118 (45)

-

213 (31)

chemotaxis

148 (62)

132 (46)

-

194 (23)

coagulation

145 (73)

111 (39)

-

184 (26)

complement

253 (155)

151 (53)

-

404 (119)

cytokine

531 (256)

439 (164)

-

695 (222)

immunity

132 (101)

125 (94)

-

226 (26)

immunodeficiency

562 (485)

103 (26)

-

588 (213)

inflammation

159 (103)

119 (63)

-

222 (34)

phagocytosis

64 (36)

44 (16)

-

80 (11)

Total Unique

5466 (1925)

3937 (1106)

2025 (204)

6798 (2403)

  1. Number of genes returned for a subset of the keywords used in the example study [10] for each database (GeneCards, Harvester and NCBI). The genes returned by a specific keyword and only this database are in parenthesis. The Total Unique column gives the total number of unique genes for each keyword with unique genes returned only by this keyword in parenthesis. The Total Unique row gives the total number of unique genes for each database with genes returned only by this database in parenthesis. The intersection of the Total Unique row and the Total Unique column gives total number of unique genes with genes returned by only one database, and the number in parenthesis gives the number of genes returned by only one database and only one keyword. - indicates that a keyword was not used with a database. As some composite keywords used in the study [10] were omitted for clarity, the totals in this Table reflect the total number of genes retrieved, not the sums of the columns.