Table 1 Parameters of linear models in MLDA for 16 cell lines in DMH dataset I

cell line

intercetp (α)

slope (β)

σ

R2

intercept_ds (α)

slope_ds (β)

σ _ds

R2_ds

A2780

-0.0003

1.0122

0.1727

0.9829

0.0005

1.0574

0.1897

0.978

A2780p3

-0.0003

1.0343

0.1212

0.9897

0.0018

1.1065

0.1425

0.9882

A2780p5

-0.0003

1.0138

0.1684

0.984

-0.0002

1.0728

0.1425

0.9883

A2780p6

0.0002

0.9914

0.1605

0.9778

-0.0001

1.0012

0.1638

0.9747

A2780p13

-0.0012

1.024

0.1628

0.9786

-0.0005

1.0744

0.1436

0.9852

A2780p14

-0.0022

1.0499

0.1523

0.9809

-0.0009

1.034

0.2069

0.9691

A2780cp70

0.0013

0.9604

0.2532

0.9524

-0.0002

1.0119

0.2402

0.9479

MCP1

0.0002

0.9946

0.145

0.9803

-0.0023

1.112

0.1452

0.9836

MCP2

0.0000

0.998

0.137

0.9727

-0.0028

1.0475

0.1719

0.9653

MCP3

0.0004

0.9932

0.2253

0.9183

-0.0023

1.0517

0.2795

0.8978

MCP4

0.0006

0.9838

0.1739

0.9718

-0.0028

1.077

0.1947

0.9751

MCP5

0.0009

0.9857

0.2464

0.9639

-0.0008

1.017

0.2166

0.9692

MCP6

-0.0022

1.0352

0.122

0.9751

-0.0068

1.1283

0.154

0.9752

MCP7

-0.0005

1.0079

0.1379

0.9791

-0.0045

1.1529

0.1588

0.9764

MCP8

-0.0028

1.0578

0.1903

0.9431

-0.0068

1.1193

0.1885

0.9575

MCP9

-0.0017

1.0331

0.1834

0.9614

-0.0091

1.1538

0.1691

0.9674

Methylation linear regression model

cell line

intercetp (α)

slope (β)

σ

R2

intercept_ds (α)

slope_ds (β)

σ _ds

R2_ds

A2780

-0.8839

0.8917

0.1491

0.9438

-0.8055

0.9086

0.1706

0.926

A2780p3

-1.1672

0.9797

0.1518

0.9553

-0.7414

0.9774

0.179

0.9438

A2780p5

-0.8991

0.8978

0.1515

0.9476

-0.9246

0.9766

0.1673

0.9523

A2780p6

-0.9455

0.9562

0.1838

0.9378

-1.1995

0.9641

0.1788

0.9324

A2780p13

-1.8918

0.9807

0.2535

0.8962

-1.8049

0.9652

0.2936

0.8512

A2780p14

-1.5637

0.9142

0.2549

0.8857

-1.4468

0.9066

0.2128

0.8837

A2780cp70

-1.0317

0.8501

0.1581

0.9115

-1.3074

0.8967

0.1541

0.9265

MCP1

-1.199

0.9781

0.1692

0.9467

-1.0935

1.0384

0.1775

0.9525

MCP2

-0.8037

0.9292

0.1486

0.9557

-0.9738

0.9381

0.2176

0.8848

MCP3

-1.1244

0.9151

0.1755

0.9482

-0.9303

0.9205

0.2599

0.8098

MCP4

-1.4326

0.9171

0.1418

0.966

-1.6205

0.961

0.2348

0.8323

MCP5

-1.1187

0.9425

0.1839

0.9404

-1.2007

0.9546

0.1757

0.9295

MCP6

-1.246

0.925

0.1966

0.9294

-1.2182

0.9826

0.2248

0.8989

MCP7

-1.8972

0.9909

0.1977

0.9442

-1.4894

1.0139

0.2458

0.8886

MCP8

-1.0219

0.9905

0.1975

0.9468

-0.4735

0.9421

0.228

0.8761

MCP9

-1.3399

0.9837

0.2073

0.9352

-1.1497

1.0078

0.1967

0.9115