Error detected by MisPred routine for Conflict 1: the case of the Swiss-Prot entry YL15_CAEEL The hypothetical homeobox protein C02F12.5 [EnsEMBL: C02F12.5] predicted for chromosome X contains an extracellular Kunitz_BPTI domain but was found to lack both a signal peptide and transmembrane helices. This protein, that also contains a nuclear Homeobox domain, arose through in silico fusion of a gene related to the homeobox protein HM07_CAEEL and a gene related to the Kunitz_BPTI containing protein CBG14258, Q619J1_CAEBR. (A) Alignment of YL15_CAEEL and Q619JI_CAEBR shows close homology only in the C-terminal region, highlighted in yellow. (B) Alignment of the YL15_CAEEL_corr1 and HM07_CAEEL. (C) Alignment of YL15_CAEEL_corr2 and Q619J1_CAEBR.