Table 5 MisPred analysis of human genes predicted by the EnsEMBL and NCBI's GNOMON pipelines
From: Identification and correction of abnormal, incomplete and mispredicted proteins in public databases
EnsEMBL | |||||||||
|---|---|---|---|---|---|---|---|---|---|
Conflict 1 | Number of proteins | Identified as containing an extracellular domain | Percentage | Identified as suspicious by MisPred | Percentage* | False Positives | Percentage* | True errors | Percentage* |
Homo sapiens | 2772 | 147 | 5.3% | 23 | 15.65% | ND | ND | ND | ND |
Monodelphis domestica | 10519 | 680 | 6.46% | 137 | 20.15% | ND | ND | ND | ND |
Gallus gallus | 6139 | 345 | 5.62% | 113 | 32.75% | ND | ND | ND | ND |
Danio rerio | 10289 | 860 | 8.36% | 317 | 36.86% | ND | ND | ND | ND |
Conflict 2 | Number of proteins | Identified as containing an extra- and an intracellular domain | Percentage | Identified as suspicious by MisPred | Percentage* | False Positives | Percentage* | True errors | Percentage* |
Homo sapiens | 2772 | 1 | 0.04% | 0 | 0.00% | 0 | 0.00% | 0 | 0.00% |
Monodelphis domestica | 10519 | 10 | 0.1% | 0 | 0.00% | 0 | 0.00% | 0 | 0.00% |
Gallus gallus | 6139 | 2 | 0.03% | 0 | 0.00% | 0 | 0.00% | 0 | 0.00% |
Danio rerio | 10289 | 20 | 0.19% | 5 | 25% | 4 | 20% | 1 | 5% |
Conflict 3 | Number of proteins | Â | Â | Identified as suspicious by MisPred | Percentage* | False Positives | Percentage* | True errors | Percentage* |
Homo sapiens | 2772 | Â | Â | 0 | 0.00% | 0 | 0.00% | 0 | 0.00% |
Monodelphis domestica | 10519 | Â | Â | 0 | 0.00% | 0 | 0.00% | 0 | 0.00% |
Gallus gallus | 6139 | Â | Â | 0 | 0.00% | 0 | 0.00% | 0 | 0.00% |
Danio rerio | 10289 | Â | Â | 0 | 0.00% | 0 | 0.00% | 0 | 0.00% |
Conflict 4 | Number of proteins | Proteins containing domains suitable for the study of domain integrity | Percentage | Identified as suspicious by MisPred | Percentage* | False Positives | Percentage* | True errors | Percentage* |
Homo sapiens | 2772 | 722 | 26.05% | 48 | 6.65% | ND | ND | ND | ND |
Monodelphis domestica | 10519 | 3726 | 35.42% | 119 | 3.19% | ND | ND | ND | ND |
Gallus gallus | 6139 | 1640 | 26.72% | 159 | 9.70% | ND | ND | ND | ND |
Danio rerio | 10289 | 2565 | 24.93% | 197 | 7.68% | ND | ND | ND | ND |
Conflict 5 | Number of proteins | Â | Â | Identified as suspicious by MisPred | Percentage* | False Positives | Percentage* | True errors | Percentage* |
Homo sapiens | 2772 | Â | Â | 0 | 0.00% | 0 | 0.00% | 0 | 0.00% |
Danio rerio | 10289 | Â | Â | 0 | 0.00% | 0 | 0.00% | 0 | 0.00% |
NCBI/GNOMON | |||||||||
Conflict 1 | Number of proteins | Identified as containing an extracellular domain | Percentage | Identified as suspicious by MisPred | Percentage* | False Positives | Percentage* | True errors | Percentage* |
Homo sapiens | 3012 | 139 | 4.61% | 32 | 23.02% | ND | ND | ND | ND |
Monodelphis domestica | 9703 | 642 | 6.62% | 112 | 17.45% | ND | ND | ND | ND |
Gallus gallus | 5604 | 310 | 5.53% | 88 | 28.39% | ND | ND | ND | ND |
Danio rerio | 8905 | 742 | 8.33% | 158 | 21.29% | ND | ND | ND | ND |
Conflict 2 | Number of proteins | Identified as containing an extra- and an intracellular domain | Percentage | Identified as suspicious by MisPred | Percentage* | False Positives | Percentage* | True errors | Percentage* |
Homo sapiens | 3012 | 2 | 0.07% | 0 | 0% | 0 | 0.00% | 0 | 0.00% |
Monodelphis domestica | 9703 | 17 | 0.18% | 4 | 23.53% | 2 | 11.76% | 2 | 11.76% |
Gallus gallus | 5604 | 3 | 0.05% | 1 | 33.33% | 1 | 33.33% | 0 | 0.00% |
Danio rerio | 8905 | 16 | 0.18% | 6 | 37.5% | 4 | 25% | 2 | 12.5% |
Conflict 3 | Number of proteins | Â | Â | Identified as suspicious by MisPred | Percentage* | False Positives | Percentage* | True errors | Percentage* |
Homo sapiens | 3012 | Â | Â | 0 | 0.00% | 0 | 0.00% | 0 | 0.00% |
Monodelphis domestica | 9703 | Â | Â | 1 | 0.01% | 0 | 0.00% | 1 | 0.01% |
Gallus gallus | 5604 | Â | Â | 0 | 0.00% | 0 | 0.00% | 0 | 0.00% |
Danio rerio | 8905 | Â | Â | 2 | 0.02% | 1 | 0.01% | 1 | 0.01% |
Conflict 4 | Number of proteins | Proteins containing domains suitable for the study of domain integrity | Percentage | Identified as suspicious by MisPred | Percentage* | False Positives | Percentage* | True errors | Percentage* |
Homo sapiens | 3012 | 792 | 26.3% | 41 | 5.18% | ND | ND | ND | ND |
Monodelphis domestica | 9703 | 3420 | 35.25% | 39 | 1.14% | ND | ND | ND | ND |
Gallus gallus | 5604 | 1500 | 26.77% | 208 | 13.87% | ND | ND | ND | ND |
Danio rerio | 8905 | 2059 | 23.12% | 300 | 14.57% | ND | ND | ND | ND |
Conflict 5 | Number of proteins | Â | Â | Identified as suspicious by MisPred | Percentage* | False Positives | Percentage* | True errors | Percentage* |
Homo sapiens | 3012 | Â | Â | 1 | 0.03% | 0 | 0.00% | 1 | 0.03% |
Danio rerio | 8905 | Â | Â | 5 | 0.06% | 5 | 0.06% | 0 | 0.00% |