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Table 4 Over-represented annotation terms in genes selected by CASh.

From: Combining Shapley value and statistics to the analysis of gene expression data in children exposed to air pollution

Functional Category Term efc p-value
SP_PIR_KEYWORDS Lectin 2,898 0,010
SP_PIR_KEYWORDS elongation factor 5,367 0,011
SP_PIR_KEYWORDS sh3 domain 2,402 0,014
SP_PIR_KEYWORDS Symport 3,340 0,015
GOTERM_MF_ALL translation elongation factor activity 4,579 0,019
GOTERM_MF_ALL sugar binding 2,564 0,021
BIOCARTA h_mapkPathway:MAPKinase Signaling Pathway 2,627 0,022
UP_SEQ_FEATURE cross-link:Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in & ubiquitin)* 4,318 0,023
COG_KOG_ONTOLOGY Inorganic ion transport and metabolism 3,378 0,023
UP_SEQ_FEATURE repeat:Solcar 3 6,045 0,023
INTERPRO_NAME IPR001452:Src homology-3 2,183 0,026
GOTERM_MF_ALL FAD binding 5,698 0,027
SP_PIR_KEYWORDS Disease mutation 9,661 0,032
UP_SEQ_FEATURE repeat:Solcar 1 5,374 0,032
UP_SEQ_FEATURE repeat:Solcar 2 5,374 0,032
SP_PIR_KEYWORDS ubl conjugation 2,115 0,032
UP_SEQ_FEATURE metal ion-binding site:Magnesium (via carbonyl oxygen) 9,068 0,036
INTERPRO_NAME IPR001440:Tetratricopeptide TPR_1 2,478 0,038
INTERPRO_NAME IPR013026:Tetratricopeptide region 2,478 0,038
SP_PIR_KEYWORDS protease 1,668 0,038
GOTERM_BP_ALL tRNA processing 3,707 0,040
SMART_NAME SM00326:SH3 2,113 0,041
INTERPRO_NAME IPR011990:Tetratricopeptide-like helical 2,116 0,043
GOTERM_MF_ALL carbohydrate binding 2,1019 0,044
SP_PIR_KEYWORDS Transferase 4,684 0,048
SP_PIR_KEYWORDS Ubl conjugation* 4,684 0,048
BIOCARTA h_gleevecpathway:Inhibition of Cellular Proliferation by Gleevec 4,446 0,051
UP_SEQ_FEATURE domain:SH3* 2,303 0,053
KEGG_PATHWAY HSA04540:GAP JUNCTION* 2,813 0,055
GOTERM_CC_ALL obsolete cellular component* 4,403 0,056
SMART_NAME SM00028:TPR 2,452 0,059
GOTERM_MF_ALL purine nucleotide binding* 1,253 0,061
SMART_NAME SM00177:ARF* 4,086 0,067
SP_PIR_KEYWORDS inner membrane 2,373 0,069
GOTERM_CC_ALL spindle pole 6,604 0,069
SP_PIR_KEYWORDS transport 1,305 0,069
GOTERM_MF_ALL aspartic-type endopeptidase activity 6,411 0,073
INTERPRO_NAME IPR002067:Mitochondrial carrier protein 3,907 0,076
GOTERM_BP_ALL biopolymer metabolism* 1,153 0,080
GOTERM_BP_ALL secretion 1,719 0,084
BIOCARTA h_erkPathway:Erk1/Erk2 Mapk Signaling pathway 3,613 0,086
BIOCARTA h_fMLPpathway:fMLP induced chemokine gene expression in HMC-1 cells 3,613 0,086
GOTERM_MF_ALL nucleotide binding* 1,201 0,087
SP_PIR_KEYWORDS lipid transport 3,680 0,088
SP_PIR_KEYWORDS nucleotide-binding 1,253 0,088
GOTERM_MF_ALL microtubule binding 3,663 0,089
GOTERM_BP_ALL macromolecule metabolism* 1,100 0,092
SP_PIR_KEYWORDS endocytosis 2,800 0,097
GOTERM_BP_ALL DNA metabolism 1,375 0,098
INTERPRO_NAME IPR005123:2OG-Fe(II) oxygenase* 5,442 0,099
  1. Overview of significant over-represented functional themes and pathways within the lists of most significant 434 genes selected by CASh. Only functional terms and pathways with p-value smaller than 0.1 are listed. The enrichment fold change (efc) is shown in the third column. Terms which are significantly over-represented also in genes from t-test (Table 5) are marked by *.