Figure 3

Functional consistency of interacting protein pairs sorted by their similarity in a descending order. We compared the same similarity measurements to those in Figure 2 by functional consistency. Using the sorted interacting pairs by their similarity in a descending order, we calculated the average functional consistency for every 500 pairs. The functional consistency of a pair is computed by the ratio of the number of common functions to the number of all distinct functions that the two proteins have. The general pattern of functional consistency is similar to that of functional co-occurrence in Figure 2. When we use the annotation-based similarity, the functional consistency monotonically decreases as the similarity of interacting pairs declines.