Table 1 Motif associated with histological grades or prognosis identified based on independent datasets
From: Integrative bioinformatics analysis of transcriptional regulatory programs in breast cancer cells
| Â | aMotif ID | bReproducibility | cP value for training data | dP value for test data |
|---|---|---|---|---|
|  | JSP$NF_Y(20) | 20 | 3.1 × 10-10 | 0.000158 |
|  | V$NRF1_Q6(10) | 15 | 3.09 × 10-14 | 6.02 × 10-7 |
motifs associated with histological grades based on the data by Sotiriou et al. | V$ELK1_02(20) | 12 | 9.25 × 10-26 | 1.41 × 10-6 |
|  | DME$CTTCCGSYN(5) | 9 | 5.71 × 10-14 | 6.82 × 10-5 |
|  | V$E2F1_Q4_01(5) | 7 | 5.71 × 10-15 | 0.002372 |
|  | JSP$NF_Y(10) | 15 | 2.46 × 10-14 | 0.011049 |
|  | DME$RMSYSSARGCGC(5) | 11 | 4.02 × 10-5 | 0.063412 |
|  | V$ELK1_02(10) | 10 | 2.03 × 10-16 | 2.08 × 10-7 |
motifs associated with prognosis based on the data by Sotiriou et al. | DME$YYYGSGCMYGCG(5) | 8 | 1.65 × 10-9 | 0.008054 |
|  | V$E2F1_Q4_01(10) | 8 | 1.05 × 10-17 | 2.37 × 10-5 |
|  | V$IRF_Q6_01(10) | 7 | 2.06 × 10-8 | 0.000152 |
| Â | DME$NMSTTCYKSYR(5) | 6 | 0.000669 | 0.084446 |
|  | V$NRF1_Q6(20) | 6 | 9.02 × 10-22 | 1.31 × 10-6 |
|  | JSP$NF_Y(20) | 22 | 5.93 × 10-8 | 0.01116 |
motifs associated with histological grades based on the data by Pawitan et al. | V$E2F1_Q4_01(5) | 10 | 6.56 × 10-7 | 0.049423 |
|  | DME$RCRKGCGCAVN(5) | 6 | 5.71 × 10-8 | 0.060899 |
|  | V$E2F1_Q4_01(15) | 6 | 9.59 × 10-6 | 0.017285 |
|  | V$ELK1_02(20) | 16 | 1.26 × 10-27 | 6.13 × 10-12 |
|  | V$NRF1_Q6(15) | 11 | 9.2 × 10-23 | 3.89 × 10-7 |
motifs associated with prognosis based on the data by Pawitan et al. | V$NRF1_Q6(20) | 11 | 4.31 × 10-22 | 2.49 × 10-7 |
|  | V$ELK1_02(15) | 9 | 1.63 × 10-25 | 6.41 × 10-11 |
|  | DME$RCGCHKGCGY(5) | 6 | 3.23 × 10-20 | 4.8 × 10-6 |