Figure 2
From: Automatically extracting functionally equivalent proteins from SwissProt
The FOSTA filtering process: homologues are identified by BLAST-ing against the UniProtKB/Swiss-Prot database (filtering stage (1)); these are then filtered to retain only those with similar function (filtering stage (2)); finally one protein per species (the FEP, or functionally equivalent protein) is chosen using a hierarchy of functional matches to eliminate functionally diverged homologues (FDHs) (filtering stage (3)).