Figure 7

A two-group two dimensional comparison of 37 NSCLC and 16 SCLC cancer cell lines. First, segmentation analysis is performed to delineate gains and losses in each sample. Next, a statistical comparison of the distribution of gains and losses between the two groups is done using the Fisher's exact test. (A) Using the interactive search, one of the regions of difference identified is on chromosome 7, with a NSCLC and SCLC sample aligned next to each other. The NSCLC has a clear segmental gain of that region, with the SCLC not having the gain. The right-most graph is a frequency plot summary of two sample sets (NSCLC and SCLC). NSCLC is color-coded in red while SCLC in green, and the overlap appears in yellow. The frequency of chromosome arm 7p gain is higher in the red group. (B) A heatmap is shown representing 15 NSCLC and 15 SCLC gene expression profiles, of the specific genes in the region highlighted in yellow. (C) When examining gene expression data of EGFR specifically, a gene in this region, we can see that the expression is drastically higher in NSCLC vs. SCLC, as predicted by the higher frequency of gain in NSCLC vs. SCLC of that region. Gene expression data are represented as log2 of the normalized intensities.