TY - JOUR AU - Rougemont, Jacques AU - Amzallag, Arnaud AU - Iseli, Christian AU - Farinelli, Laurent AU - Xenarios, Ioannis AU - Naef, Felix PY - 2008 DA - 2008/10/13 TI - Probabilistic base calling of Solexa sequencing data JO - BMC Bioinformatics SP - 431 VL - 9 IS - 1 AB - Solexa/Illumina short-read ultra-high throughput DNA sequencing technology produces millions of short tags (up to 36 bases) by parallel sequencing-by-synthesis of DNA colonies. The processing and statistical analysis of such high-throughput data poses new challenges; currently a fair proportion of the tags are routinely discarded due to an inability to match them to a reference sequence, thereby reducing the effective throughput of the technology. SN - 1471-2105 UR - https://doi.org/10.1186/1471-2105-9-431 DO - 10.1186/1471-2105-9-431 ID - Rougemont2008 ER -