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Table 4 Detailed results for hot-spot predicted residues (NIP ≥ 0.4) with available experimental data.

From: Identification of hot-spot residues in protein-protein interactions by computational docking

Complex

Number of predicted residues(NIP ≥ 0.4)

hot-spot prediction success(PPV)

Number of near-native posesa

1BRS

5

100%

25

1BXI

6

67%

6

1DFJ

3

100%

8

1DN2

1

100%

5

1F47

3

67%

1

1JCK

7

100%

0b

1JRH

2

50%

10

1NMB

1

100%

0c

1VFB

9

67%

1

3HFM

3

100%

0d

1IAR

7

71%

1

1AIE

4

50%

3

  1. aNumber of near-native solutions (RMSD ≤ 10 Å) within the ensemble of 100 lowest-energy docking orientations used to calculate the NIP values; bbest RMSD within the ensemble is 22.0 Å; cbest RMSD is 20.9 Å; dbest RMSD is 12.2 Å.