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Figure 7 | BMC Bioinformatics

Figure 7

From: Volume-based solvation models out-perform area-based models in combined studies of wild-type and mutated protein-protein interfaces

Figure 7

ΔΔ(ASA-NP) does not correlate with ΔΔG EXP , and is of variable sign. (a) ΔΔ(ASA-NP) calculated with Minimal-HighSA packing does not correlate with ΔΔGEXP (R2 = 0.00), and can be positive or negative (red line drawn at ΔΔ(ASA-NP) = 0). (b) Qualitatively similar behaviour to that for panel (a) is seen for Complete-LowSA repacking (R2 = 0.02). (c) Reducing the solvent probe radius from 1.4 Å to 0.5 Å gives mostly uniform sign of ΔΔ(ASA-NP), but still poor correlation with ΔΔGEXP (R2 = 0.18).

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