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Table 1 Wild-type complexes and binding energies.

From: Volume-based solvation models out-perform area-based models in combined studies of wild-type and mutated protein-protein interfaces

Protein A

Protein B

ΔG (kJ/mole)

PDB

Ref

BPTI

Chymotrypsin

-44.96

1CBW

[49]

Barnase

Barstar

-79.50

1B27

[50]

Subtilisin Carlsberg

OMTKY3

-59.31

1R0R

[51]

Rap1A

Raf1

-35.98

1C1Y

[52]

Ras

Byr2

-38.45

1K8R

[53]

Fv D1.3

Fv E5.2

-45.48

1DVF

[54]

Fv D1.3

HEWL

-45.10

1VFB

[55]

BPTI

Trypsin

-75.16

2PTC

[49]

HyHEL10 Fab

HEWL

-56.21

3HFM

[56]

RalGDS

Ras

-35.15

1LFD

[57]

Subtilisin Carlsberg

Eglin C

-54.76

1CSE

[58]

IM9

Colicin E9

-78.62

1EMV

[59]

HyHEL5 Fab

HEWL

-59.36

1YQV

[60]

SGPB

OMTKY3

-61.45

3SGB

[61]

Ribonuclease Inhibitor

Angiogenin

-87.15

1A4Y

[62]

N9 Neuraminidase

NC10 Fab

-48.50

1NMB

[63]

Subtilisin BPN'

SSI

-61.33

2SIC

[64]

Thrombin

Thrombomodulin

-53.09

1DX5

[65]

Ribonuclease A

Ribonuclease Inhibitor

-76.30

1DFJ

[62]

Kallikrein A

BPTI

-51.83

2KAI

[66]

  1. Protein constituents of the complexes are given, with the following abbreviations: OMTKY3, turkey ovomucoid third domain; HEWL, Hen Egg White Lysozyme; BPTI, Bovine Pancreatic Trypsin Inhibitor; IM9, Immunity Protein 9; SGPB Streptomyces griseus protease B; SSI, Streptomyces Subtilisin Inhibitor.