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Table 1 List of ORFs containing C-, O- and N-Methyltransferase domains

From: In silico analysis of methyltransferase domains involved in biosynthesis of secondary metabolites

Name of gene cluster

ORF

Accession no.

CDD search

Types of MT-domain

Total

    

C-MT

O-MT

N-MT

 
    

NRPS clusters

  

Actinomycin

acmC

AAF42473

PF08242

-

-

2

2

Anabaenopeptilide

apdB

CAC01604

PF08242

-

-

2

 
 

apdE

CAC01607

PF08241

-

1

-

3

Complestatin

comC

AAK81826

PF08242

-

-

1

1

Cyclosporine

simA

CAA82227

PF08242

-

-

7

7

Enniatin

esyn1

CAA79245

PF08242

-

-

1

1

Pristinamycin

snbDE

T30289

PF08242

-

-

1

1

Pyochelin

pchF

AAD55801

PF08242

-

-

1

1

Thaxtomin

txtA

AAG27087

PF08242

-

-

1

 
 

txtB

AAG27088

COG2226

-

-

1

2

    

PKS clusters

  

Compactin

mlcA

BAC20564

PF08242

1

-

-

 
 

mlcB

BAC20566

PF08242

1

-

-

2

Erythromycin

eryG

CAA42929

COG2226

-

1

-

1

Equisetin

eqiS

AAV66106

PF08242

1

-

-

1

Fumonisin

fum1

AAD43562

PF08242

1

-

-

1

Lovastatin

lovB

Q9Y8A5

PF08242

1

-

-

 
 

lovF

AAD34559

PF08242

1

-

-

2

Stigmatellin

stiD

CAD19088

PF08242

-

1

-

 
 

stiE

CAD19089

PF08242

-

1

-

 
 

stiK

CAD19094

PF01209

-

1

-

3

    

Hybrid NRPS-PKS

  

Bleomycin

blmVIII

AAG02357

PF08242

1

-

-

1

Barbamide

barF

AAN32980

PF08242

-

1

-

 
 

barG

AAN32981

PF08242

-

-

1

2

Epothilone

epoD

AAF26922

PF08242

1

-

-

1

Jamaicamide A

jamJ

AAS98781

PF08242

1

-

-

 
 

jamN

AAS98785

COG0500

-

1

-

2

Leinamycin

lnmJ

AAN85523

PF08242

1

-

-

1

Melithiazol

melE

CAD89776

PF08242

-

1

-

 
 

melF

CAD89777

PF08242

-

1

-

2

Microcystin

mcyD

BAB12210

PF08242

1

-

-

 
 

mcyE

BAB12211

-

1

-

-

 
 

mcyG

BAB12213

PF08242

1

-

-

 
 

mcyA

BAA83992

PF08242

-

-

1

4

Myxothiazol

mtaE

AAF19813

PF08242

-

1

-

 
 

mtaF

AAF19814

PF08242

-

1

-

2

Nodularin

ndaC

AAO64404

-

1

-

-

 
 

ndaD

AAO64405

PF08242

1

-

-

 
 

ndaF

AAO64407

-

1

-

-

 
 

ndaA

AAO64403

PF08242

-

-

1

 
 

ndaE

AAO64406

PF08242

-

1

-

5

Onnamide

onnB

AAV97870

PF08242

-

1

-

 
 

onnD

AAV97872

PF08242

-

1

-

 
 

onnG

AAV97875

PF08242

-

1

-

 
 

onnH

AAV97876

COG2226

-

1

-

 
 

onnI

AAV97877

PF08242

-

1

-

5

Pederin

pedF

AAS47564

PF08242

1

-

-

 
 

pedA

AAS47557

PF08241

-

1

-

 
 

pedE

AAS47560

COG2226

-

1

-

3

Tubulysin

tubF

CAF05651

PF08242

1

-

-

 
 

tubB

CAF05647

PF08242

-

-

1

 
 

tubC

CAF05648

PF08242

-

-

1

3

Yersiniabactin

HMWP-1

AAC69588

PF08242

2

-

-

2

Total

   

20

19

22

61

  1. List of ORFs containing methyltransferase domains in various experimentally characterized NRPS/PKS gene clusters. Table also lists the number and type of MT domains in each of the ORFs and results from PFAM analysis using CDD search.
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BMC Bioinformatics

ISSN: 1471-2105

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