Figure 6

Illustration of frequency-weighted phenotype congruency. The distance between points reflects the relative number of genes that share (or lack) the corresponding phenotype. Phenotypic signatures for a single gene are represented as a line; phenotypes correspond to individual vertical bars. The length of the gray area in a phenotype's bar is proportional to its frequency. The presence of a phenotype for a gene is indicated by drawing a point at the extremes of the shaded area for the phenotype. The total distance between the lines reflects the relative dissimilarity of the gene pair. A. Two genes which share frequently occurring present and absent phenotypes, and so would receive a poor information-based score. B. Two genes which share rare present and absent phenotypes, and so would receive a good information-based score.