Figure 1
From: Gene set enrichment analysis for non-monotone association and multiple experimental categories
log 10 (ALT ratio) vs log 2 (gene expression ratio). Examples of non-monotone relationship in liver between expression levels of two genes and ALT. Each color represents one compound, and symbols (○, Δ, +) indicate the low, medium and high doses respectively. For the compound (diquat) with four dose levels, symbol "×" indicates the highest dose. Time information is not indicated. The smoothing line is fitted using all data, with natural cubic splines.