TY - JOUR AU - Westholm, Jakub Orzechowski AU - Xu, Feifei AU - Ronne, Hans AU - Komorowski, Jan PY - 2008 DA - 2008/11/17 TI - Genome-scale study of the importance of binding site context for transcription factor binding and gene regulation JO - BMC Bioinformatics SP - 484 VL - 9 IS - 1 AB - The rate of mRNA transcription is controlled by transcription factors that bind to specific DNA motifs in promoter regions upstream of protein coding genes. Recent results indicate that not only the presence of a motif but also motif context (for example the orientation of a motif or its location relative to the coding sequence) is important for gene regulation. SN - 1471-2105 UR - https://doi.org/10.1186/1471-2105-9-484 DO - 10.1186/1471-2105-9-484 ID - Westholm2008 ER -