Anti-correlation between motif frequency and nucleosome occupancy. A) An example of anti-correlation between motif frequency and nucleosome occupancy. The black curve shows the distribution of Ste12 binding motifs within promoters bound by Ste12. The red curve shows the average nucleosome occupancy levels around these Ste12 sites. The correlation in this example is -0.79. B) Histogram over the correlation between motif frequency and nucleosome occupancy for all 280 motif-experiment pairs from the TF-DNA interaction data. Pairs with a significant location bias (in red) have significantly lower correlations (p-value 2.9e-3) than pairs without correlation bias (blue).