Figure 2

Distribution of gene-pathway correlation loss, prostate data. Distribution of loss of correlation between normal and tumor samples (ie, signed S_GPC) in the prostate data set (red) and 6 permutation resamplings (black) of all pairs. While not exhaustive, the few resamplings show a much narrower distribution centered around zero; none of the resampled pairs exhibited values exceding S = 0.9. By contrast, the observed distribution is wider, and biased towards loss of correlation in tumor samples with respect to normal samples.