TY - BOOK AU - Stephanopoulos, G. AU - Aristidou, A. AU - Nielsen, J. PY - 1998 DA - 1998// TI - Metabolic engineering PB - Academic Press CY - San Diego ID - Stephanopoulos1998 ER - TY - JOUR AU - Nielsen, J. PY - 2001 DA - 2001// TI - Metabolic Engineering JO - Applied Microbiology and Biotechnology VL - 55 UR - https://doi.org/10.1007/s002530000511 DO - 10.1007/s002530000511 ID - Nielsen2001 ER - TY - JOUR AU - Tomita, M. PY - 2001 DA - 2001// TI - Whole-cell simulation: a grand challenge of the 21st century JO - Trends in Biotechnology VL - 19 UR - https://doi.org/10.1016/S0167-7799(01)01636-5 DO - 10.1016/S0167-7799(01)01636-5 ID - Tomita2001 ER - TY - JOUR AU - Kauffman, K. J. AU - Prakash, P. AU - Edwards, J. S. PY - 2003 DA - 2003// TI - Advances in flux balance analysis JO - Curr Opin Biotechnol VL - 14 UR - https://doi.org/10.1016/j.copbio.2003.08.001 DO - 10.1016/j.copbio.2003.08.001 ID - Kauffman2003 ER - TY - JOUR AU - Ibarra, R. U. AU - Edwards, J. S. AU - Palsson, B. O. PY - 2002 DA - 2002// TI - Escherichia coli K-12 undergoes adaptive evolution to achieve in silico predicted optimal growth JO - Nature VL - 420 UR - https://doi.org/10.1038/nature01149 DO - 10.1038/nature01149 ID - Ibarra2002 ER - TY - JOUR AU - Burgard, A. P. AU - Pharkya, P. AU - Maranas, C. D. PY - 2003 DA - 2003// TI - OptKnock: A bilevel programming framework for identifying gene knockout strategies for microbial strain optimization JO - Biotechnology and Bioengineering VL - 84 UR - https://doi.org/10.1002/bit.10803 DO - 10.1002/bit.10803 ID - Burgard2003 ER - TY - JOUR AU - Patil, K. R. AU - Rocha, I. AU - Forster, J. AU - Nielsen, J. PY - 2005 DA - 2005// TI - Evolutionary programming as a platform for in silico metabolic engineering JO - BMC Bioinformatics VL - 6 UR - https://doi.org/10.1186/1471-2105-6-308 DO - 10.1186/1471-2105-6-308 ID - Patil2005 ER - TY - JOUR AU - Segre, D. AU - Vitkup, D. AU - Church, G. M. PY - 2002 DA - 2002// TI - Analysis of optimality in natural and perturbed metabolic networks JO - Proceedings of the National Academy of Sciences of the United States of America VL - 99 UR - https://doi.org/10.1073/pnas.232349399 DO - 10.1073/pnas.232349399 ID - Segre2002 ER - TY - BOOK AU - Michalewicz, Z. PY - 1996 DA - 1996// TI - Genetic Algorithms + Data Structures = Evolution Programs UR - https://doi.org/10.1007/978-3-662-03315-9 DO - 10.1007/978-3-662-03315-9 ID - Michalewicz1996 ER - TY - STD TI - Syswerda G: Uniform crossover in Genetic Algorithms. In Proc. 3rd Intl Conference on Genetic Algorithms 1989. San Mateo: Morgan Kaufmann; 2–9. ID - ref10 ER - TY - BOOK AU - De Jong, K. PY - 1975 DA - 1975// TI - An analysis of the Bahavior of a Class of Genetic Adaptive Systems ID - De Jong1975 ER - TY - JOUR AU - Kirkpatrick, S. AU - Gellatt, C. D. AU - Vecchi, M. P. PY - 1983 DA - 1983// TI - Optimization by Simulated Annealing JO - Science VL - 220 UR - https://doi.org/10.1126/science.220.4598.671 DO - 10.1126/science.220.4598.671 ID - Kirkpatrick1983 ER - TY - JOUR AU - Lee, S. Y. AU - Hong, S. H. AU - Moon, S. Y. PY - 2002 DA - 2002// TI - In Silico metabolic pathway analysis and design: succinic acid production by metabolically engineered Escherichia coli as an example JO - Genome Informatics VL - 13 ID - Lee2002 ER - TY - JOUR AU - Hofvendahl, K. AU - Hahn-Hagerdal, B. PY - 2000 DA - 2000// TI - Factors affecting the fermentative lactic acid production from renewable resources JO - Enzyme and Microbial Technology VL - 26 UR - https://doi.org/10.1016/S0141-0229(99)00155-6 DO - 10.1016/S0141-0229(99)00155-6 ID - Hofvendahl2000 ER - TY - JOUR AU - John, R. P. AU - Nampoothiri, K. M. AU - Pandey, A. PY - 2007 DA - 2007// TI - Fermentative production of lactic acid from biomass: an overview on process developments and future perspectives JO - Applied Microbiology and Biotechnology VL - 74 UR - https://doi.org/10.1007/s00253-006-0779-6 DO - 10.1007/s00253-006-0779-6 ID - John2007 ER - TY - JOUR AU - Chang, D. E. AU - Jung, H. C. AU - Rhee, J. S. AU - Pan, J. G. PY - 1999 DA - 1999// TI - Homofermentative production of D- or L-lactate in metabolically engineered Escherichia coli RR1 JO - Appl Environ Microbiol VL - 65 ID - Chang1999 ER - TY - JOUR AU - Zhou, S. D. AU - Causey, T. B. AU - Hasona, A. AU - Shanmugam, K. T. AU - Ingram, L. O. PY - 2007 DA - 2007// TI - Production of optically pure D-lactic acid in mineral salts medium by metabolically engineered Escherichia coli W3110 JO - Applied and Environmental Microbiology VL - 69 UR - https://doi.org/10.1128/AEM.69.1.399-407.2003 DO - 10.1128/AEM.69.1.399-407.2003 ID - Zhou2007 ER - TY - JOUR AU - Forster, J. AU - Famili, I. AU - Fu, P. AU - Palsson, B. O. AU - Nielsen, J. PY - 2003 DA - 2003// TI - Genome-scale reconstruction of the Saccharomyces cerevisiae metabolic network JO - Genome Res VL - 13 UR - https://doi.org/10.1101/gr.234503 DO - 10.1101/gr.234503 ID - Forster2003 ER - TY - JOUR AU - Reed, J. L. AU - Vo, T. D. AU - Schilling, C. H. AU - Palsson, B. O. PY - 2003 DA - 2003// TI - An expanded genome-scale model of Escherichia coli K-12 (iJR904 GSM/GPR) JO - Genome Biology VL - 4 UR - https://doi.org/10.1186/gb-2003-4-9-r54 DO - 10.1186/gb-2003-4-9-r54 ID - Reed2003 ER - TY - JOUR AU - Lin, H. AU - Bennett, G. N. AU - San, K. Y. PY - 2005 DA - 2005// TI - Genetic reconstruction of the aerobic central metabolism in Escherichia coli for the absolute aerobic production of succinate JO - Biotechnol Bioeng VL - 89 UR - https://doi.org/10.1002/bit.20298 DO - 10.1002/bit.20298 ID - Lin2005 ER - TY - JOUR AU - Alper, H. AU - Miyaoku, K. AU - Stephanopoulos, G. PY - 2005 DA - 2005// TI - Construction of lycopene-overproducing E. coli strains by combining systematic and combinatorial gene knockout targets JO - Nature Biotechnololy VL - 23 UR - https://doi.org/10.1038/nbt1083 DO - 10.1038/nbt1083 ID - Alper2005 ER - TY - JOUR AU - Klamt, S. AU - Stelling, J. PY - 2002 DA - 2002// TI - Combinatorial complexity of pathway analysis in metabolic networks JO - Mol Biol Rep VL - 29 UR - https://doi.org/10.1023/A:1020390132244 DO - 10.1023/A:1020390132244 ID - Klamt2002 ER - TY - JOUR AU - Stelling, J. AU - Klamt, S. AU - Bettenbrock, K. AU - Schuster, S. AU - Gilles, E. D. PY - 2002 DA - 2002// TI - Metabolic network structure determines key aspects of functionality and regulation JO - Nature VL - 420 UR - https://doi.org/10.1038/nature01166 DO - 10.1038/nature01166 ID - Stelling2002 ER - TY - JOUR AU - Deutscher, D. AU - Meilijson, I. AU - Kupiec, M. AU - Ruppin, E. PY - 2006 DA - 2006// TI - Multiple knockout analysis of genetic robustness in the yeast metabolic network JO - Nature Genetics VL - 38 UR - https://doi.org/10.1038/ng1856 DO - 10.1038/ng1856 ID - Deutscher2006 ER -