Natural computation meta-heuristics for the in silico optimization of microbial strains

BMC Bioinformatics

Table 4 Best overall mutants obtained for each case study

CASE STUDY	BPCY	List of knockouts
S. cerevisiae, succinate, aerobic	0.05398	PGI1_1, PGI1_2, FBP1, PDC6, ADH4, SDH3_2, AAH1_1, URH1_1, U30_, MET3, ALD4_2, GSH1, U103_, YER053C, CTP1_1*
E. coli, lactate, aerobic	0.39850	ALCD19, DRPA, GLYCDx, F6PA, TPI, LDH_D2, EDA, TKT2, LDH_D-
E. coli, lactate, anaerobic	0.25527	FRD3, GART, ADHEr *
E. coli, succinate, aerobic	0.35785	MALS, ORNDC, FUM, GLYCL, GHMT2, ADPT, DCYTD, DUTPDP, URIDK2r, NTD8, PUNP1, THD2, GND, PFL, SUCFUMt *

This table shows the list of knockouts in the best solution found in all the runs of both algorithms. In the rows marked with *, other solutions with the same BPCT exist; the one with less knockouts was selected (see Additional file 2 for the complete list)

ISSN: 1471-2105