Figure 8

Relative angle change difference and % angle change difference with PCA. The distributions of the relative angle change differences (A and B) and of the % angle change differences (C and D) in ten randomly sampled sets of 80,000 gene pairs are plotted for each number of top PCs kept (2 to 59) in PCA. A positive correlation range in the angle before (< 0.3 π, A and C) and a negative correlation range in the angle before (> 0.7 π, B and D) are shown separately. In (A) and (C), the smaller the difference values are, the selectivity in preferential correlation increase with the gene pairs sharing GO terms is higher. In (B) and (D), the larger the difference values are, the selectivity is higher. In comparison, the distribution of the difference values obtained by RSPR-NR in ten randomly-sampled gene pairs is shown on the right of each panel.