Figure 1From: The contrasting properties of conservation and correlated phylogeny in protein functional residue predictionFragment of an Example Alignment. Illustration of the difference between highly conserved positions likely to be responsible for core structure and/or function and specificity-defining (SD) positions of a multiple sequence alignment. Columns 1 and 2 illustrate positions crucial in all family members. Column 3 shows a similar, though less stringent global pattern of conservation. Column 4 in contrast represents an SD position, where only a single amino acid is tolerated by each subfamily. Column 5 represents a non-conserved position for comparison.Back to article page