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Figure 1 | BMC Bioinformatics

Figure 1

From: The contrasting properties of conservation and correlated phylogeny in protein functional residue prediction

Figure 1

Fragment of an Example Alignment. Illustration of the difference between highly conserved positions likely to be responsible for core structure and/or function and specificity-defining (SD) positions of a multiple sequence alignment. Columns 1 and 2 illustrate positions crucial in all family members. Column 3 shows a similar, though less stringent global pattern of conservation. Column 4 in contrast represents an SD position, where only a single amino acid is tolerated by each subfamily. Column 5 represents a non-conserved position for comparison.

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