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Figure 3 | BMC Bioinformatics

Figure 3

From: The contrasting properties of conservation and correlated phylogeny in protein functional residue prediction

Figure 3

Surface Accessibility of Domain Residues. Illustration of surface accessibility of positions associated with functional residue prediction in the four different interface subtypes of the BW05 validation data [37]. Distributions of relative solvent accessibility (RSA) are shown in divided into 3 bins: buried (B, 0 ≤ RSA < 5), partly buried (PB, 5 ≤ RSA < 25), and accessible (A, 25 ≤ RSA < 100). Of the three columns of panels, the far left (labeled 'Interacting Positions' represents all positions found interacting in the BW05 dataset. Centre panels illustrate positions over the domain as a whole, while right-hand panels are derived from SMERFS or Williamson predictions. The lighter 'caps' on bars in the 'Predictions' column represent the portion that corresponds to interactions in the BW05 set. Rows describe the sub-types of hetero-obligates, homo-obligates, enzyme-inhibitors and non-enzyme inhibitor transient (NEIT).

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