Interaction Type | Conservation Measure | Reference | ROC0.1 score (standard) | Parameters | ROC0.1 score (optimised) | Score Difference | |
---|---|---|---|---|---|---|---|
 |  |  |  | W | C g |  |  |
Domain | Williamson | [28] | 0.0087 | 3 | 1 | 0.0098 | 0.0011 |
 | Kabat | [29] | 0.0079 | 5 | 1 | 0.0088 | 0.0009 |
 | Karlin | [31] | 0.0074 | 7 | 1 | 0.0086 | 0.0012 |
 | Sander | [36] | 0.0078 | 3 | 1 | 0.0083 | 0.0005 |
 | Valdar | [32] | 0.0075 | 7 | 1 | 0.0081 | 0.0006 |
 | Taylor | [33] | 0.0070 | 9 | 1 | 0.0080 | 0.0010 |
 | Zvelebil | [52] | 0.0070 | 9 | 1 | 0.0079 | 0.0009 |
 | SMERFS |  | 0.0056 | 9 | 1 | 0.0071 | 0.0015 |
 | Armon | [14] | 0.0063 | 9 | 0.8 | 0.0067 | 0.0004 |
 | Jores | [30] | 0.0050 | 9 | 0.9 | 0.0064 | 0.0014 |
 | Schneider | [36] | 0.0049 | 5 | 0.6 | 0.0062 | 0.0013 |
 | Gerstein | [35] | 0.0049 | 5 | 0.6 | 0.0062 | 0.0013 |
 | Thompson | [26] | 0.0060 | 7 | 1 | 0.0062 | 0.0002 |
 | Mirny | [34] | 0.0059 | 9 | 0.7 | 0.0057 | -0.0002 |
 | Randomscore |  | 0.0048 | 7 | 1 | 0.0052 | 0.0004 |
 | Lancet | [27] | 0.0008 | 1 | 0.3 | 0.0051 | 0.0043 |
Small Molecule | Williamson | [28] | 0.0114 | 5 | 1 | 0.0122 | 0.0008 |
 | Kabat | [29] | 0.0128 | 3 | 1 | 0.0120 | -0.0008 |
 | Valdar | [32] | 0.0120 | 1 | 1 | 0.0120 | 0.0000 |
 | Taylor | [33] | 0.0113 | 1 | 1 | 0.0113 | 0.0000 |
 | Karlin | [31] | 0.0121 | 9 | 1 | 0.0110 | -0.0011 |
 | Thompson | [26] | 0.0073 | 1 | 0.9 | 0.0108 | 0.0035 |
 | Zvelebil | [52] | 0.0110 | 9 | 1 | 0.0108 | -0.0002 |
 | Armon | [14] | 0.0107 | 1 | 1 | 0.0107 | 0.0000 |
 | Schneider | [36] | 0.0091 | 1 | 0.8 | 0.0102 | 0.0011 |
 | Gerstein | [35] | 0.0091 | 1 | 0.8 | 0.0102 | 0.0011 |
 | Lancet | [27] | 0.0014 | 1 | 0.2 | 0.0097 | 0.0083 |
 | Sander | [36] | 0.0091 | 3 | 1 | 0.0093 | 0.0002 |
 | Jores | [30] | 0.0090 | 9 | 0.8 | 0.0090 | 0.0000 |
 | SMERFS |  | 0.0057 | 9 | 1 | 0.0079 | 0.0022 |
 | Mirny | [34] | 0.0089 | 9 | 0.6 | 0.0078 | -0.0011 |
 | Randomscore |  | 0.0049 | 7 | 1 | 0.0053 | 0.0004 |
Combined | Williamson | [28] | 0.0107 | 5 | 1 | 0.0112 | 0.0005 |
 | Kabat | [29] | 0.0106 | 3 | 1 | 0.0108 | 0.0002 |
 | Karlin | [31] | 0.0099 | 7 | 1 | 0.0108 | 0.0009 |
 | Valdar | [32] | 0.0100 | 7 | 1 | 0.0102 | 0.0002 |
 | Taylor | [33] | 0.0093 | 9 | 1 | 0.0098 | 0.0005 |
 | Zvelebil | [52] | 0.0091 | 9 | 1 | 0.0097 | 0.0006 |
 | Sander | [36] | 0.0091 | 3 | 1 | 0.0096 | 0.0005 |
 | Schneider | [36] | 0.0064 | 5 | 0.5 | 0.0078 | 0.0014 |
 | Gerstein | [35] | 0.0064 | 5 | 0.5 | 0.0078 | 0.0014 |
 | SMERFS |  | 0.0057 | 9 | 1 | 0.0077 | 0.0020 |
 | Armon | [14] | 0.0083 | 9 | 0.8 | 0.0076 | -0.0007 |
 | Jores | [30] | 0.0066 | 9 | 0.9 | 0.0074 | 0.0008 |
 | Lancet | [27] | 0.0009 | 1 | 0.2 | 0.0073 | 0.0064 |
 | Thompson | [26] | 0.0065 | 9 | 1 | 0.0068 | 0.0003 |
 | Mirny | [34] | 0.0074 | 9 | 0.7 | 0.0067 | -0.0007 |
 | Randomscore |  | 0.0049 | 7 | 1 | 0.0053 | 0.0004 |