Figure 6
From: Global rank-invariant set normalization (GRSN) to reduce systematic distortions in microarray data
GRSN reduces average variance in datasets. Lowess curves are plotted summarizing the variance (for log base 2 scaled data) of all genes among selected sets of replicate samples and whole datasets. The curves show the trend in the variance as a function of expression values. Dashed blue is RMA processed data and dashed red is RMA processed data with GRSN post processing. A. RS dataset showing variance reduction in Control samples, Myc samples, and control and Myc samples combined. B. SS dataset showing, WT samples, mutant samples, and WT and mutant samples combined.