Pareto front. a) Pareto front of optimal composite motifs corresponding to a multi-objective optimization with respect to support, distance restriction and specificity (hit-probability). Red colors show high specificity and blue colors show low specificity. b) Corresponding layout of motifs where colors instead denote combined motif score (significance). Red colors correspond to highest-ranked motifs according to combined score. The top-ranked composite motif is located at support 5 and distance window 200.