AnEnPi: identification and annotation of analogous enzymes

BMC Bioinformatics

Table 2 Examples of analogy Found in The literature and the Methods used.

EC	Enzyme	Organism	Ref.	Method
1.1.1.42	Isocitrate dehydrogenase	Escherichia coli/Azotobacter vinelandii	[7]	a
2.7.1.4	Fructokinase	Homo sapiens/Streptococcus mutans	[7]	a
3.2.1.86	6-phospho-beta-glucosidase	E. coli/H. sapiens	[7]	a
3.4.21.72	Immunoglobulin A (IgA) proteases	Streptococcus sanguis/Neisseria gonorhoeae	[27]	a
2.1.1.-	N-methyltransferase 1	Schizosaccharomyces pombe/Chlamydia pneumoniae/Archaeoglobus fulgidus	[9]	a, b
2.7.7.-	Adenylyltransferase	Bacillus subtilis/Saccharomyces cerevisiae	[9]	a, b
3.1.3.11	Fructose-1,6-bisphosphatase	Prochlorococcus marinus/E. coli	[28]	c
2.3.1.-	Enoyl thioester reductase	E. coli/Yeast/Rat	[29]	d
1.13.11.2	Catechol 2,3-dioxygenase	Pseudomonas sp./TOL plasmid (pww0)	[30]	e
2.7.2.3	Glyceric acid 3-phosphate kinase	Pisum sativum	[31]	f
5.3.1.1	Triose phosphate isomerase	Pisum sativum	[31]	f

Table 2: a – computational, b – genetic complementation, c – genome sequencing, d – stereochemical assay, e – biochemical assay and f – isoelectric focusing

ISSN: 1471-2105