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Table 3 Comparison of cross-validation results for predicting promoters and enhancers.

From: Prediction of regulatory elements in mammalian genomes using chromatin signatures

Combination

Promoter PPVa (standard deviation)

Enhancer PPV (standard deviation)

HMM method using 6 histone signaturesb

97.87% (1.06)

93.52%(1.83)

HMM method using 2 histone signaturesc

95.46% (2.82)

94.06% (0.89)

Heintzman et al. using 6 histone signatures

96%

78%

Heintzman et al. using 2 histone signatures

95%

85%

  1. aPositive predictive value (PPV) = true prediction/(true prediction + wrong prediction) and standard deviation are calculated.
  2. b6 histone signatures: H4ac, H3ac, H3Kme1, H3K4me2, H3K4me3, H3
  3. c2 histone signatures: H3Kme1, H3K4me3