Figure 1
Top nine disease state comparisons showing differential expression of Nanog. A single gene search for Nanog showed that it was measured in 5706 experimental conditions, and differentially expressed in 19 disease states in human studies (fold > 2, q ≤ 0.05). Bar colors represent q-values, length represents fold change, and width represents rank percentile. Long, wide, red bars show increased significance. It was 20.2-fold upregulated in the sperm cells with abnormal morphology compared to controls. It was significantly downregulated in the PBMC from malaria infected patients compared to uninfected controls (fold = 4.5, q < 0.0005) and presymptomatic infected patients (fold = 3.4, q < 0.0005). It was also significantly downregulated in multiple independent cancer studies, including 13.3-fold downregulation in primary malignant melanoma samples, 3.6-fold downregulation in metastatic prostate cancer tumors and 3.4-fold downregulation in the plasma cells from patients with plasma cell leukemia.