Figure 2

Comparisons resulting differential expression of Nanog , Oct4 and Sox2. A multiple gene search for Nanog, Oct4 (pou5f1), and Sox2 in human studies showed that they were all significantly upregulated in abnormal sperm morphology, and downregulated in malaria infection and cancer. Nanog (fold = 20.2, q < 0.0005), Oct4 (fold = 2.0, q < 0.0005) and Sox2 (fold = 2.3, q < 0.0005) were all significantly upregulated in the abnormal sperm morphology compared to controls. Nanog (fold = 4.5, q < 0.0005), Oct4 (fold = 2.3, q < 0.0005) and Sox2 (fold = 3.0, q < 0.0005) were all significantly downregulated in the PBMC from malaria infected patients compared to controls. They were also significantly downregulated in various types of cancers, such as plasma cell leukemia and malignant melanoma. Clicking the average q-values and fold changes opens values for individual genes.