Figure 1

Graphical representation of the normalised CAIhm, defined as the quotient between the CAI of a gene and its expected value, versus G+C content at the third codon positions for the human genes that encode a subunit of a complex of the mitochondrial respiratory chain. Red squares represent mitochondrial genes encoded in the human mitochondrial genome and blue dots represent mitochondrial genes encoded in the human nuclear genome. An expected value of CAI was estimated for each gene with the E-CAI server, using the Poisson method and a 95% interval confidence and a 99% population coverage.